Effect OF ISOFLAVONE ON MEMORY IN RAT MODEL OF SURGICALLY INDUCED MENOPAUSE; POSSIBLE ROLE OF GLUTAMATE AND GAMMA AMINO BUTYRIC ACID.
Abouhammad, W., Hassan, M., Hussien, N., Shoman, A., Mostafa, R. (2021). Effect OF ISOFLAVONE ON MEMORY IN RAT MODEL OF SURGICALLY INDUCED MENOPAUSE; POSSIBLE ROLE OF GLUTAMATE AND GAMMA AMINO BUTYRIC ACID.. EKB Journal Management System, 38(2), 671-685. doi: 10.21608/bmfj.2021.60372.1375
Wessam Abouhammad; Mahmoud Mostafa Hassan; Noha Ibrahim Hussien; Abeer Ahmed Shoman; Randa Mohammed Mostafa. "Effect OF ISOFLAVONE ON MEMORY IN RAT MODEL OF SURGICALLY INDUCED MENOPAUSE; POSSIBLE ROLE OF GLUTAMATE AND GAMMA AMINO BUTYRIC ACID.". EKB Journal Management System, 38, 2, 2021, 671-685. doi: 10.21608/bmfj.2021.60372.1375
Abouhammad, W., Hassan, M., Hussien, N., Shoman, A., Mostafa, R. (2021). 'Effect OF ISOFLAVONE ON MEMORY IN RAT MODEL OF SURGICALLY INDUCED MENOPAUSE; POSSIBLE ROLE OF GLUTAMATE AND GAMMA AMINO BUTYRIC ACID.', EKB Journal Management System, 38(2), pp. 671-685. doi: 10.21608/bmfj.2021.60372.1375
Abouhammad, W., Hassan, M., Hussien, N., Shoman, A., Mostafa, R. Effect OF ISOFLAVONE ON MEMORY IN RAT MODEL OF SURGICALLY INDUCED MENOPAUSE; POSSIBLE ROLE OF GLUTAMATE AND GAMMA AMINO BUTYRIC ACID.. EKB Journal Management System, 2021; 38(2): 671-685. doi: 10.21608/bmfj.2021.60372.1375

Effect OF ISOFLAVONE ON MEMORY IN RAT MODEL OF SURGICALLY INDUCED MENOPAUSE; POSSIBLE ROLE OF GLUTAMATE AND GAMMA AMINO BUTYRIC ACID.

Benha Medical Journal
Article 21, Volume 38, Issue 2, July 2021, Page 671-685  XML PDF (502.04 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2021.60372.1375
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Authors
Wessam Abouhammad email 1; Mahmoud Mostafa Hassan2; Noha Ibrahim Hussien3; Abeer Ahmed Shoman4; Randa Mohammed Mostafa5
1department of physiology, faculty of medicine Benha university
2department of physiology faculty of medecine Benha university
3Department of physiology,Faculty of medicine,Benha university.
4department of physiology faculty of medicine Benha university
5Physiology Department-Faculty of Medicine-Benha University
Abstract
Background: Menopause is a biological process that can cause various troublesome symptoms such as hot flashes and emotional changes but can also affect cognitive functions. Soy isoflavones (SIF), are natural compounds that gained popularity as an alternative treatment for menopausal symptoms. Aim: The aim of this work was to investigate the effect of isoflavone treatment on memory in ovariectomized female albino rats. Method: 32 female albino rats were divided into 4 groups consisting of 8 rats in each group; sham, Sham+isoflavone, bilateral Ovariectomy (OVX), OVX + isoflavone. After isoflavone treatment , the animals underwent the novel object recognition test (NORT), and their performance was evaluated. at the end of the experiment. Gaba amino butyric acid (GABA) and glutamate were measured in hippocampal tissues and hormonal level of follicle stimulating hormone (FSH) & 17β-estradiol (E2) were measured in serum.
Results: Animals with ovariectomy showed significant increase (P
Keywords
Ovariectomy; Isoflavone; Cognition; GABA; Glutamate
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