EFFECT OF METHIDATHION ON THE CYTOCHROME P-450 ENZYMES IN THE NILE TILAPIA OREOCHROMIS NILOTICVS | ||||
| Egyptian Journal of Aquatic Biology and Fisheries | ||||
| Article 19, Volume 5, Issue 4, September 2001, Page 319-329 PDF (489.21 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejabf.2001.1723 | ||||
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| Abstract | ||||
| An experiment was conduced on adult male and female Nile tilapia to investigate the effect of Methidathion (MD,is one of the more toxic organophosphates) MD at doses 3 \xg l"1 '10 jig l"1,20 jag r'on the microsomal of ethoxy-resrufin o-deethylase activity (EROD). The experimental fish was obtained from Manzala Lake from the areas suffering from pollution. Result revealed that activity of EROD in female livers jig/kg/ fresh liver was (3,33,25,17,12) for MD concentrations 3|igl_i; 1 Opgl"1 ;20jigl*!, Control and IC groups, respectively. Analysis of variance indicated that differences among the tested groups were not significant P<o.o5 for females. Whereas for males were significant P<o.o5 (10,153,105,97and 58).The results also indicated that EROD activity in livers of tilapia males was the highest at MD lower concentrations was due to the resistance of fish against MD at the concentrations 10 (ig V1 and 20 fig T1' then it decreased at higher concentrations indicating that resistance against MD decreased which will be reflected on growth performance and fish activity. These results indicated that fish males, in general, showed better resistances against toxins compared to females, | ||||
| Keywords | ||||
| Oreochromis niloticus, EROD, Cytochrome P-450 organophosphate; xenobiotics, hormones, Manzala Lake | ||||
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