Extended Letrozole Therapy for Ovulation Induction in clomiphene resistant Women with Polycystic Ovary Syndrome | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 7, Volume 73, Issue 7, October 2018, Pages 7032-7036 PDF (457.71 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2018.17230 | ||
| Authors | ||
| Mohammad Salah El-Dein Hassanein1; Mostafa Hussein Hegab1; Attia Mohammad Attia1; Mostafa Ahmed Abd El-Maksoud Zayed2 | ||
| 1Department Of Obstetrics and Gynecology, Al-Azhar Faculty of Medicine, Cairo | ||
| 2Obstetrics and Gynecology at Manshiet El-Bakry General Hospital | ||
| Abstract | ||
| Objective: This study aimed to evaluate the efficacy of short and extended long course of letrozole therapy for ovulation induction in clomiphene resistant women with polycystic ovary syndrome. Patients: One hundred infertile women were selected from the patients attending the outpatient clinic of Manshiet El-Bakry general hospital. All patients were diagnosed as having anovulation due to polycystic ovary syndrome (PCOS). Interventions: Patients were randomly allocated to treatment with either long letrozole group took 2.5 mg of letrozole daily starting day 1 of spontaneous or progesterone inducing menstrual bleeding for 10 days (50 patients, up to 3 cycles) or short letrozole group took 5 mg of letrozole daily starting day 1 of spontaneous or progesterone inducing menstrual bleeding for 5 days (50 patients, up to 3 cycles). Results:The number of ovulating patients was greater in the long letrozole group (74% vs. 56%), but without statistical differences. The total number of follicles during stimulation was insignificantly greater in the long letrozole group (8.2 vs. 8.17). The numbers of follicles ≥18 mm were significantly greater in the long letrozole group. Pregnancy occurred in 7 in the short group (14%) and 12 of (24%) in the long letrozole group, and the difference was statistically insignificant. Conclusion: The long letrozole protocol (10 days) can produce more mature follicles and subsequently more pregnancies than the short letrozole therapy (5 days). | ||
| Keywords | ||
| Extended Letrozole; Ovulation Induction; clomiphene resistance; PCOs | ||
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