68Ga-PSMA Uptake in Lymphoma: A Potential Pitfall in Prostate Cancer PET Imaging.
M, D., M, H., S, N., S, D., S, S., J, M. (2021). 68Ga-PSMA Uptake in Lymphoma: A Potential Pitfall in Prostate Cancer PET Imaging.. EKB Journal Management System, 22(1), 89-91. doi: 10.21608/egyjnm.2021.172755
Di Tamba, M; Haffejee, M; Nayler, S; Dhoodhat, S; Shamsuddeen, S; Momodu, J. "68Ga-PSMA Uptake in Lymphoma: A Potential Pitfall in Prostate Cancer PET Imaging.". EKB Journal Management System, 22, 1, 2021, 89-91. doi: 10.21608/egyjnm.2021.172755
M, D., M, H., S, N., S, D., S, S., J, M. (2021). '68Ga-PSMA Uptake in Lymphoma: A Potential Pitfall in Prostate Cancer PET Imaging.', EKB Journal Management System, 22(1), pp. 89-91. doi: 10.21608/egyjnm.2021.172755
M, D., M, H., S, N., S, D., S, S., J, M. 68Ga-PSMA Uptake in Lymphoma: A Potential Pitfall in Prostate Cancer PET Imaging.. EKB Journal Management System, 2021; 22(1): 89-91. doi: 10.21608/egyjnm.2021.172755

68Ga-PSMA Uptake in Lymphoma: A Potential Pitfall in Prostate Cancer PET Imaging.

Egyptian Journal Nuclear Medicine
Article 7, Volume 22, Issue 1, May and June 2021, Page 89-91  XML PDF (392.27 K)
Document Type: Case Report
DOI: 10.21608/egyjnm.2021.172755
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Authors
Di Tamba, M1; Haffejee, M2; Nayler, S3; Dhoodhat, S1; Shamsuddeen, S1; Momodu, J1
1Division of Nuclear Medicine and Molecular Imaging, Department of Radiation Sciences, University of the Witwatersrand.
2Surgical Faculty Practice, Wits University Donald Gordon Medical Centre.
3Department of Anatomical Pathology, National Health Laboratory Service, South Africa.
Abstract
Receptor targeted imaging using prostate specific membrane antigen (PSMA)-a labeled radioisotope currently plays a key role in prostate cancer imaging. This is due to the overexpression of PSMA, a type II Tran's membrane protein, in prostate cancer cells. Gallium-68 and fluorine-18 labeled PSMA are currently available for positron emission tomography/ computed tomography (PET/CT) imaging for the diagnosis, staging, treatment planning and follow-up of prostate cancer.
In this case report we discuss a 70 year old male who presented with progressively rising serum prostate-specific antigen (PSA) levels. Three prostate biopsies performed at different time points were negative and failed to provide a histological diagnosis. 68Ga-PSMA PET/CT was subsequently requested to guide biopsy and appropriately stage the disease. PSA level at the time of imaging was 39ng/ml. Uptake was demonstrated in the left posterior-lateral aspect of the prostate gland (SUVmax=15.27), identifying the target biopsy site for histological confirmation of the diagnosis of prostate cancer (Figure 1).
Unusual uptake was also noted in a right axillary lymph node (SUVmax=6.18). Biopsy of this lymph node confirmed Hodgkin’s Lymphoma (Figure 2&3).This clinical case demonstrates the non-specific nature of PSMA in prostate cancer, despite its name. We would like to advise caution in the interpretation of distant nodal uptake sites on 68Ga-PSMA PET/CT imaging for the diagnosis and/or staging of prostate cancer.
Keywords
Prostate cancer; 68Ga-PSMA; Lymphoma; Hodgkin’s lymphoma
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