Value of Serum Copeptin Estimation in the Diagnosis of Kidney Injury in Preeclampsia
Ghorab, A., Al-Barshomy, S., Mahmoud, O., Shahein, M., Sakla, N. (2023). Value of Serum Copeptin Estimation in the Diagnosis of Kidney Injury in Preeclampsia. EKB Journal Management System, 29(3), 753-760. doi: 10.21608/zumj.2021.66861.2167
Adel Abdelmohsen Ghorab; Said Al-Barshomy; Osama Abd-Elaziz Mahmoud; Mohamed Said Abdulaziz Shahein; Niveen Shafeek Shokry Sakla. "Value of Serum Copeptin Estimation in the Diagnosis of Kidney Injury in Preeclampsia". EKB Journal Management System, 29, 3, 2023, 753-760. doi: 10.21608/zumj.2021.66861.2167
Ghorab, A., Al-Barshomy, S., Mahmoud, O., Shahein, M., Sakla, N. (2023). 'Value of Serum Copeptin Estimation in the Diagnosis of Kidney Injury in Preeclampsia', EKB Journal Management System, 29(3), pp. 753-760. doi: 10.21608/zumj.2021.66861.2167
Ghorab, A., Al-Barshomy, S., Mahmoud, O., Shahein, M., Sakla, N. Value of Serum Copeptin Estimation in the Diagnosis of Kidney Injury in Preeclampsia. EKB Journal Management System, 2023; 29(3): 753-760. doi: 10.21608/zumj.2021.66861.2167

Value of Serum Copeptin Estimation in the Diagnosis of Kidney Injury in Preeclampsia

Zagazig University Medical Journal
Article 2, Volume 29, Issue 3, May and June 2023, Page 753-760  XML PDF (334.71 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.66861.2167
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Authors
Adel Abdelmohsen Ghorab1; Said Al-Barshomyorcid 2; Osama Abd-Elaziz Mahmoud3; Mohamed Said Abdulaziz Shahein4; Niveen Shafeek Shokry Sakla email 5
1Professor of Internal Medicine Department, Nephrology and Transplantation Unit, Faculty of Medicine, Zagazig University
2Assistant Professor of Internal Medicine Department Faculty of Medicine, Zagazig University
3Professor of Medical Biochemistry, Faculty of Medicine, Zagazig University
4Nephrology Consultant, al-Mouwasat Hospital, Khobar, KSA
5Assistant Professor of Internal Medicine Department, Nephrology Unit, Faculty of Medicine,Zagazig University
Abstract
Background: Copeptin is a peptide secreted from the hypothalamus, with the arginine vasopressin (AVP). Also, as copeptin is excreted by the kidneys and is stable in plasma, it can be used as a biomarker for AVP secretion. Aim: This study was conducted to evaluate the role of serum copeptin in the diagnosis of kidney injury in pregnant females with preeclampsia.
Methods: This study included a total of 60 women; 20 pregnant with preeclampsia, 20 with normal pregnancy, and 20 healthy non-pregnant control. The following investigations had been made; HbA1C, blood urea, serum creatinine, serum uric acid, creatinine clearance, glomerular filtration rate (GFR), urinary protein, urinary sodium (Na), liver function tests, and serum copeptin levels were measured by an enzyme-linked immunoassay (ELISA).
Results: Serum copeptin levels in pg/ml mean±SD were significantly higher in preeclampsia (3778.5±265.45) than in normal pregnancy (1452.9±397.81), and non-pregnant control (253.88±294.6) (p < 0.05) (S). Serum copeptin showed a positive correlation with the blood pressure, HbA1C, serum creatinine, uric acid, bilirubin, ALT and AST, urinary Na, blood urea, and urinary proteins (p < 0.05) (S), and a negative correlation with the GFR and creatinine clearance (p < 0.05) (S). Receiver Operating Characteristic (ROC) curve for serum copeptin as a marker for kidney injury in preeclampsia; at a cutoff point 3100 pg/ml, showed 95.0% sensitivity, 85.0% specificity (p < 0.05) (S).
Conclusion: Serum copeptin can be used as a marker for the diagnosis of kidney injury in preeclampsia, with high sensitivity and specificity.
Keywords
Serum copeptin; preeclampsia; kidney injury; arginine vasopressin; AVP
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