COVID-19: Variable Immune Response in Indian Population
Das, S., Gupta, C., Akhter, N., Jain, C., Sonthalia, S., Ahmad, S., Dar, S. (2021). COVID-19: Variable Immune Response in Indian Population. EKB Journal Management System, 13(1), 133-147. doi: 10.21608/eajbsc.2021.173938
Shukla Das; Chhavi Gupta; Naseem Akhter; Charu Jain; Sidharth Sonthalia; Saif Ahmad; Sajad Ahmad Dar. "COVID-19: Variable Immune Response in Indian Population". EKB Journal Management System, 13, 1, 2021, 133-147. doi: 10.21608/eajbsc.2021.173938
Das, S., Gupta, C., Akhter, N., Jain, C., Sonthalia, S., Ahmad, S., Dar, S. (2021). 'COVID-19: Variable Immune Response in Indian Population', EKB Journal Management System, 13(1), pp. 133-147. doi: 10.21608/eajbsc.2021.173938
Das, S., Gupta, C., Akhter, N., Jain, C., Sonthalia, S., Ahmad, S., Dar, S. COVID-19: Variable Immune Response in Indian Population. EKB Journal Management System, 2021; 13(1): 133-147. doi: 10.21608/eajbsc.2021.173938

COVID-19: Variable Immune Response in Indian Population

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Article 11, Volume 13, Issue 1, June 2021, Page 133-147  XML PDF (806.67 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2021.173938
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Authors
Shukla Das1; Chhavi Gupta2; Naseem Akhter3; Charu Jain1; Sidharth Sonthalia4; Saif Ahmad5; Sajad Ahmad Darorcid 6
1Department of Microbiology, University College of Medical Sciences (University of Delhi) & GTB Hospital, Delhi, India
2Northern Railways Central Hospital, Delhi, India
3Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha, Saudi Arabia
4Skinnocence: The Skin Clinic & Research Centre, Gurugram, India
5Barrow Neurological Institute, Phoenix, Arizona USA
6Research and Scientific Studies Unit, College of Nursing, Jazan University, Jazan, Saudi Arabia
Abstract
With a year and a half into the COVID-19 pandemic, still, variance in terms of transmission and susceptibility of different populations/ethnicities to the disease remains an enigma. The clinical outcome of COVID-19 disease is poor in patients with associated morbidities; however, the reasons behind significant mortality of immuno‐competent healthy individuals attributed to fulminant infection remains to be elucidated. Generally, protective B and T cell-mediated immune responses seem to have a tilted balance causing a sustained inflammatory state in SARS-CoV-2 infected individuals. The genetic makeup of an individual is highly likely to play a major role in elicitation as well as the outcome of the immune response in COVID‐19 cases. The Indian response to COVID-19 indicates a potential influence of genetic background on host immune response pathways leading to decreased susceptibility and mortality to SARS-CoV-2 infection. Many host genes are involved in the entry and replication of SARS‐CoV‐2 and the subsequent host immune response. The current review discusses the potential cytokine gene polymorphisms prevalent in the Indian population that may influence the transmission, severity and mortality due to COVID‐19 infection. 
Keywords
COVID-19; Immune response; Genetic makeup; Host gene polymorphism; Mortality
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