ANTIMICROBIAL PEPTIDES AS POTENT COMPOUNDS FOR REDUCTION OF COVID-19 INFECTION

Zare-Zardini, Hadi; Ferdosian, Farzad; Soltaninejad, Hossein; Zahedi, Mahlagha; Memarpoor-Yazdi, Mina; Hamidieh, Amir Ali; Aghaeimeybodi, Fatemeh; Zarezadeh, Mohammad; Eshaghi, Farzaneh Sadat; Jabinian, Fatemeh; Dehghanbaghi, Neda; Mirakhor, Mahnaz; Khnjarpanah, Zohreh

doi:10.21608/bfsa.2021.174150

	ANTIMICROBIAL PEPTIDES AS POTENT COMPOUNDS FOR REDUCTION OF COVID-19 INFECTION
Bulletin of Pharmaceutical Sciences Assiut University
Article 23, Volume 44, Issue 1, June 2021, Page 243-252 PDF (549.88 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2021.174150
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Authors
Hadi Zare-Zardini¹; Farzad Ferdosian²; Hossein Soltaninejad³; Mahlagha Zahedi⁴; Mina Memarpoor-Yazdi⁵; Amir Ali Hamidieh⁶; Fatemeh Aghaeimeybodi⁷; Mohammad Zarezadeh⁸; Farzaneh Sadat Eshaghi⁹; Fatemeh Jabinian¹⁰; Neda Dehghanbaghi¹¹; Mahnaz Mirakhor¹²; Zohreh Khnjarpanah¹²
¹Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran & Department of Sciences, Farhangian University, Isfahan, Iran & Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
²Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran & Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
³Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
⁴Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
⁵Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
⁶Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran
⁷Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences,Yazd, Iran
⁸Health Policy and Management Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
⁹Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
¹⁰Department of Operating Room and Anesthesiology, School of Allied Medical Sciences, Yazd, Iran
¹¹Department of Biology, Faculty of Science, Science and Art University, Iran
¹²Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
COVID-19 is an infectious disease caused by a new identified coronavirus in china, SARS-COV2. There are no efficient treatments for COVID-19. Therefore, it is essential to investigate new therapies for this problem. Due to specific mechanism for inhibition of microbial growth, antimicrobial peptides can be considered as one of the best therapies in this field. Antimicrobial peptides (AMPs) are important agents that are made by the immune system in response to pathogens. This kind of immune response exists in all animal categories from prokaryotes to humans. Different types of AMPs have been identified and isolated from various organisms from bacteria to humans. So far, 190 antiviral peptides with antiviral effects have been extracted and introduced from various animal sources. These natural compounds and their derivatives, e.g. synthetic peptides, can be considered as new therapeutic goals in COVID-19. In this review, we assessed these peptides in different animal categories as well as synthetic peptides and the possibility of using these compounds in the treatment of COVID-19.


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