Pharmacokinetics of ceftiofur sodium after intravenous and subcutaneous administration in pre-weaned calves
El-hewaity, M. (2021). Pharmacokinetics of ceftiofur sodium after intravenous and subcutaneous administration in pre-weaned calves. EKB Journal Management System, 17(1), 71-83. doi: 10.21608/evmspj.2021.174688
Mohamed H. El-hewaity. "Pharmacokinetics of ceftiofur sodium after intravenous and subcutaneous administration in pre-weaned calves". EKB Journal Management System, 17, 1, 2021, 71-83. doi: 10.21608/evmspj.2021.174688
El-hewaity, M. (2021). 'Pharmacokinetics of ceftiofur sodium after intravenous and subcutaneous administration in pre-weaned calves', EKB Journal Management System, 17(1), pp. 71-83. doi: 10.21608/evmspj.2021.174688
El-hewaity, M. Pharmacokinetics of ceftiofur sodium after intravenous and subcutaneous administration in pre-weaned calves. EKB Journal Management System, 2021; 17(1): 71-83. doi: 10.21608/evmspj.2021.174688

Pharmacokinetics of ceftiofur sodium after intravenous and subcutaneous administration in pre-weaned calves

Egyptian Veterinary Medical Society of Parasitology Journal (EVMSPJ)
Article 5, Volume 17, Issue 1, January 2021, Page 71-83  XML PDF (481.41 K)
Document Type: Original Article
DOI: 10.21608/evmspj.2021.174688
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Author
Mohamed H. El-hewaity
Departement of Pharmacology,Faculty of Veterinary Medicine,Menoufia University
Abstract
The current work was outlined to decide kinetic profile and bioavailability of ceftiofur sodium at measurements of 2.2 mg/kg. b.wt. after a single intravenous and subcutaneous injection in pre-weaned calves. Five clinically typical pre-weaned calves were utilized in this work. Serum ceftiofur concentrations were decided by utilizing high performance liquid chromatography (HPLC) strategy. The serum concentration-time curve has shown a two compartment open model. Taking after a single intravenous injection, distribution half-life (t0.5α) was 0.11 ± 0.01h, volume of distribution (Vdss) was 0.16 ± 0.004 L/kg, elimination half-life (t0.5β) was 11.07 ± 0.12h and total body clearance (CLtot) was 0.013 ± 0.005 L/kg/h. Taking after a single subcutaneous organization, ceftiofur  had a peak serum concentration (Cmax) 6.64 ± 0.08 μg/ml at a time (tmax) of 3.38 ± 0.069 h, disposal half-life (t0.5el) was 2.11 ± 0.25h demonstrating the propensity of calves to eliminate ceftiofur in slow rate. Bioavailability was 77.04 ± 1.64% after subcutaneous injection indicating a good absorption of ceftiofur. Ceftiofur serum concentrations along 36 h following subcutaneous injection in the current work were exceeding the MICs of different susceptible microorganisms responsible for serious disease problems. These results demonstrating successful use of ceftiofur in pre-weaned calves.
Keywords
ceftiofur; Pharmacokinetics; HPLC; pre-weaned calves
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