Epigenetics and Familial Mediterranean fever
Lotfy, R., Ali, O., Zarouk, W., EL-Bassyouni, H., Nour El-Din, G. (2021). Epigenetics and Familial Mediterranean fever. EKB Journal Management System, 1(2), 1-12. doi: 10.21608/aijpms.2021.63099.1047
Randa Lotfy; Ola Ali; Waheba Zarouk; Hala EL-Bassyouni; Ghada Nour El-Din. "Epigenetics and Familial Mediterranean fever". EKB Journal Management System, 1, 2, 2021, 1-12. doi: 10.21608/aijpms.2021.63099.1047
Lotfy, R., Ali, O., Zarouk, W., EL-Bassyouni, H., Nour El-Din, G. (2021). 'Epigenetics and Familial Mediterranean fever', EKB Journal Management System, 1(2), pp. 1-12. doi: 10.21608/aijpms.2021.63099.1047
Lotfy, R., Ali, O., Zarouk, W., EL-Bassyouni, H., Nour El-Din, G. Epigenetics and Familial Mediterranean fever. EKB Journal Management System, 2021; 1(2): 1-12. doi: 10.21608/aijpms.2021.63099.1047

Epigenetics and Familial Mediterranean fever

Azhar International Journal of Pharmaceutical and Medical Sciences
Article 1, Volume 1, Issue 2, June 2021, Page 1-12  XML PDF (443.57 K)
Document Type: Review Articles
DOI: 10.21608/aijpms.2021.63099.1047
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Authors
Randa Lotfy email orcid 1; Ola Ali2; Waheba Zarouk1; Hala EL-Bassyouni3; Ghada Nour El-Din1
1Department of Molecular Genetics, National Research Centre, Cairo, Egypt.
2Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
3Department of Clinical Genetics, National Research Center, Cairo, Egypt.
Abstract
Abstract:
Throughout the last 20 years, the concept of auto-inflammation is developed, culminating with the finding of how gene mutations of Mediterranean Fever (MEFV) seemed to be causally linked to Familial Mediterranean fever (FMF). The autoinflammatory illnesses presently constitute a wide variety of disorders that have mutual signs of frequent fever, the incidence of hyper-reactive immune cells of hereditary origin, and indicators of inflammation that may occur systemically or specific to an organ with no autoimmunity specific infection.The key causes of the unregulated inflammation are the myeloid innate immune cells which mainly induced production of excessive inflammatory cytokines as IL-1β and IL-18. Deficiencies through various signalling mechanisms regulating innate immune response, especially a single and even multiple inflammasomes hyperreactivity, remain the essence of pathological autoinflammatory phenotype.While FMF would be a monogenic autoinflammatory syndrome, it is genetically complicated and affected by environmental influences. Lately, epigenetic dysregulation has appeared to be a further cause of pathogenesis. Throughout this survey, we are addressing the epigenetic involvement pathways within (FMF).
Keywords
Keywords: Autoinflammatory Diseases; Epigenetics; DNA Methylation; Familial Mediterranean Fever; Gene Expression; Microbiota
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