Effect of Coconut Oil Administration on Some Hemostatic Changes Associated with Obesity in Rats | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 3, Volume 37, Issue 1, October 2009, Page 630-643 PDF (654.07 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2009.17474 | ||||
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| Authors | ||||
| Fatma Ahmed Mohamed; Nehal Mohammad Bahgat; Gehane M. Hamed; Rania S.A. Eisa | ||||
| Physiology Department, Faculty of Medicine, Ain Shams University | ||||
| Abstract | ||||
| In the last few decades, coconut oil was claimed to have some beneficial health effects, attributed mainly to its medium chain triglycerides. It was, thus, intriguing to investigate the potential benefit of coconut oil in alleviating the prothrombotic tendency often encountered in obese individuals. The present study was carried out on 44 rats, of both sexes, aged 10 days at the start of the study. 31 out of 44 rats were offered high caloric diet (the cafeteria diet) for induction of obesity. Rats were allocated into the following groups: Group1: Control rats (C) (n=13 rats), comprising rats fed on the standard chow diet all-over the study period (24 weeks). Group2: Cafeteria diet-fed rats (Caf) (n=16 rats), comprising rats fed on cafeteria diet until the end of the study period and Group3: Cafeteria diet/coconut oil-fed rats (Caf/Coco) (n=15 rats), comprising rats fed on cafeteria diet with coconut oil starting from the 16th week till the end of the study period. At the end of the study, the BMI was assessed in the 3 studied groups and blood samples were collected for determination of platelet count and aggregation, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrin degradation products (FDPs), and plasma lipid profile. The encountered results revealed that the mean BMI of the cafeteria diet-fed rats was significantly higher than the BMI of control rats, and that the mean BMI of rats receiving cafeteria/coconut oil diet for 9 weeks was significantly decreased compared to their matched caf group. The PT, APTT and platelet count were all non significantly different in the three studied groups. Platelet aggregation, on the other hand, was significantly increased in the caf group compared to the control group, and significantly decreased in the caf/coco group compared to both the caf group and the control group. The plasma FDPs levels were not significantly different in the 3 studied groups. The lipid profile was insignificantly different in the 3 studied groups except in the caf/coco group which revealed a significant elevation of total cholesterol and HDL- c compared to caf group. The present findings, thus, point to the possible beneficial effect of coconut oil feeding on obesity - induced enhanced platelet aggregation. | ||||
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