Role of miRNA manipulation on methylation states of breast cancer stem cell-related gene: Methylation status and miRNAs on BCSCs
Elosaily, H., Ibrahim, I., Essawi, M., Salem, S. (2021). Role of miRNA manipulation on methylation states of breast cancer stem cell-related gene: Methylation status and miRNAs on BCSCs. EKB Journal Management System, 1(2), 13-22. doi: 10.21608/aijpms.2021.61532.1045
Heba Elosaily; Iman Ibrahim; Mona Essawi; Sohair Salem. "Role of miRNA manipulation on methylation states of breast cancer stem cell-related gene: Methylation status and miRNAs on BCSCs". EKB Journal Management System, 1, 2, 2021, 13-22. doi: 10.21608/aijpms.2021.61532.1045
Elosaily, H., Ibrahim, I., Essawi, M., Salem, S. (2021). 'Role of miRNA manipulation on methylation states of breast cancer stem cell-related gene: Methylation status and miRNAs on BCSCs', EKB Journal Management System, 1(2), pp. 13-22. doi: 10.21608/aijpms.2021.61532.1045
Elosaily, H., Ibrahim, I., Essawi, M., Salem, S. Role of miRNA manipulation on methylation states of breast cancer stem cell-related gene: Methylation status and miRNAs on BCSCs. EKB Journal Management System, 2021; 1(2): 13-22. doi: 10.21608/aijpms.2021.61532.1045

Role of miRNA manipulation on methylation states of breast cancer stem cell-related gene: Methylation status and miRNAs on BCSCs

Azhar International Journal of Pharmaceutical and Medical Sciences
Article 2, Volume 1, Issue 2, June 2021, Page 13-22  XML PDF (832.98 K)
Document Type: Review Articles
DOI: 10.21608/aijpms.2021.61532.1045
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Authors
Heba Elosaily email orcid 1; Iman Ibrahim2; Mona Essawi3; Sohair Salem4
1Department of Biochemistry, Faculty of Pharmacy, Ahram Canadian University,12585, Giza, Egypt
2Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University, 11651, Cairo, Egypt
3Department of Medical Molecular Genetics, National Research Centre, Giza 12622, Egypt
4Department of Molecular Genetics and Enzymology, National Research Centre, Giza 12622, Egypt
Abstract
The genetic and epigenetic alteration was commonly related to the progression of breast cancer. Epigenetic alteration which comprises DNA methylation and microRNA is involved in controlling the gene expression which is related to cancer cells. The change of cellular transformation, tumorigenesis, and stemness marker were accomplished by this epigenetic modification. The short, non-coding RNAs, which are called microRNAs (miRNAs) are considered as a master regulator of genes and are associated with the management of both physiological and pathological status. The abnormal miRNAs expression was found to be contributed in the progress of many types of human tumors by disrupting the action of oncogenic and cancer suppressor genes. For the meantime, the expression of both oncogenic and tumor suppressor genes was affected by the change in the DNA methylation status. This occurs due to the hypermethylation of CpG islands within the promoter sites, that disturbs the tumor suppressing role of miRNAs in cancer. The current article will talk about the relationship of miRNAs and DNA methylation and its effect on the adjustment of gene expression.
Keywords
mi-RNA; Breast Cancer; Epigenetics; Stem Cells; Methylation
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