COMPARATIVE EFFECT BETWEEN CHITOSAN AND CHITOSAN- Cu COMPLEX ON CARBON-TETRACHLORIDE (CCL4) INDUCED LIVER DAMAGE IN RATS | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 2, Volume 36, Issue 1, July 2009, Page 397-405 PDF (280.55 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2009.17523 | ||||
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| Authors | ||||
| El-Habibi E.M; Sirag H.M; Edrees G.M | ||||
| Zoology Dept., Faculty of Science, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| BACKGROUND: Carbon tetrachloride (CCl4 ) is a toxic material known to induce lipid peroxidation and liver damage. The possible protective roles that involved by chitosan or chitosan-Cu complex against CCl4 induced liver intoxication were investigated in male rats. RESULTS: CCl4 administred at dose 20 mg/kg body weight i.p., exceed malondialdehyde (MDA) and protein carbonyle (PC), depleted superoxide dismutase (SOD) and glutathione (GSH), in concomitant with marked increase in investigated liver function parameters , alanine aminotransferase and aspartate aminotransferase (ALT, AST), impaired serum and liver total protein , albumin and globulin. An elevation in serum and hepatic total lipids, total cholesterol, triglycerides and serum LDL and VLDL levels as well as a low level of HDL were recorded. In the same time, there was a significant increase in sodium and iron contents in the serum while a significant decrease in potassium and zinc contents were recorded. Animals pretreated with chitosan (200 mg /kg body weight) orally by stomach tube for 21 consecutive days prior to CCl4 challenge significantly attenuated most of the tested parameters, strengthen antioxidant defense system, ameliorated liver function effectively. Chitosan-Cu complex has a protective effect by a higher degree than that of chitosan only. CONCLUSION: These findings suggest that pretreatment with chitosan-Cu complex has higher hepato-protective effects than that of only chitosan against CCl4 induced toxicity in rat. | ||||
| Keywords | ||||
| Carbon tetrachloride (CCl4) – Chitosan – lipid peroxidation – liver functions | ||||
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