Smart UV-Spectrophotometric methods for the simultaneous determination of amprolium-HCl, ethopabate and sulfaquinoxaline-Na in combined dosage forms
Abdelaziz, S., Abdel Razeq, S., Ahmed, N. (2021). Smart UV-Spectrophotometric methods for the simultaneous determination of amprolium-HCl, ethopabate and sulfaquinoxaline-Na in combined dosage forms. EKB Journal Management System, 1(2), 63-71. doi: 10.21608/aijpms.2021.62019.1046
Shimaa Abdelaziz; Sawsan Abdel Razeq; Nermin Ahmed. "Smart UV-Spectrophotometric methods for the simultaneous determination of amprolium-HCl, ethopabate and sulfaquinoxaline-Na in combined dosage forms". EKB Journal Management System, 1, 2, 2021, 63-71. doi: 10.21608/aijpms.2021.62019.1046
Abdelaziz, S., Abdel Razeq, S., Ahmed, N. (2021). 'Smart UV-Spectrophotometric methods for the simultaneous determination of amprolium-HCl, ethopabate and sulfaquinoxaline-Na in combined dosage forms', EKB Journal Management System, 1(2), pp. 63-71. doi: 10.21608/aijpms.2021.62019.1046
Abdelaziz, S., Abdel Razeq, S., Ahmed, N. Smart UV-Spectrophotometric methods for the simultaneous determination of amprolium-HCl, ethopabate and sulfaquinoxaline-Na in combined dosage forms. EKB Journal Management System, 2021; 1(2): 63-71. doi: 10.21608/aijpms.2021.62019.1046

Smart UV-Spectrophotometric methods for the simultaneous determination of amprolium-HCl, ethopabate and sulfaquinoxaline-Na in combined dosage forms

Azhar International Journal of Pharmaceutical and Medical Sciences
Article 8, Volume 1, Issue 2, June 2021, Page 63-71  XML PDF (673.75 K)
Document Type: Original research articles
DOI: 10.21608/aijpms.2021.62019.1046
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Authors
Shimaa Abdelaziz email 1; Sawsan Abdel Razeq1; Nermin Ahmed2
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt
Abstract
Two UV-spectrophotometric methods were adopted for simultaneous determination of amprolium HCl, ethopabate and sulfaquinoxaline-Na. The two methods are a double divisor ratio derivative method and ratio dual wavelength method. The three cited drugs were determined by the suggested methods in the range of 6.0-50.0 µg mL-1, 2.0-27.0 μg mL-1 and 3.0-25.0 µg mL-1, respectively. The proposed methods were proved to be selective where the mean percentage recoveries of amprolium HCL, ethopabate and sulfaquinoxaline-Na provided by the double divisor ratio derivative method were 99.29 ± 0.84, 100.36 ± 1.21 and 100.61-101.57 ± 0.15-1.75; respectively. The ratio dual wavelength method mean recoveries were in the range of 98.93-100.45%±0.44-1.42, 99.47-100.67%±0.83-1.65 and 99.97-101.71%±0.10-1.15 for the studied drugs; respectively. Both methods were validated following ICH guidelines. Successful application of the methods for analyzing the three drugs in their veterinary dosage forms; Ampoethoquinone powder was conducted. The obtained results were statistically analyzed and found to be in accordance with those given by the reported methods.
Keywords
Amprolium; Ethopabate; Sulfaquinoxaline; Ratio Derivative; Ratio Dual Wavelength
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