Synthesis and Characterization of Novel Pyrazole Derivatives from 4-Florophenylhydrazine and Study Their Cytotoxicity as Anti-Cancer Agent | ||||
| Egyptian Journal of Chemistry | ||||
| Article 33, Volume 64, Issue 11, November 2021, Page 6473-6480 PDF (686.7 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.78214.3825 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Sumaya M. Salih1; Hameed M. Alkubaisi2; Fadhil L. Faraj1 | ||||
| 1Department Of chemistry, college of science, university of Diyala | ||||
| 2Biotechnology and Environmental Center, University of Fallujah | ||||
| Abstract | ||||
| Series of new pyrazole derivatives have been successfully synthesized, their purity confirmed by thin-layer chromatography and the chemical structures identified by some spectroscopic techniques like 1H-NMR, APT 13C-NMR and FT-IR. Two synthetic precursors were synthesized: The first compound was 5-Fluoro-2,3,3-trimethyli-3H-indole (1) and the second compound was 2-(5-Fluoro-3,3-idimethyl-1,3dihydro-indoli-2-ylidene)-malonaldehyde (2). The target compounds were obtained from the reaction of compound (2) with different substituted phenylhydrazine hydrochloride. The toxicity of the new synthesized compounds was tested against breast cancer cell lines (MCF-7) and results showed that some cancer cells were killed. | ||||
| Keywords | ||||
| Heterocyclic; pyrazole derivatives and breast cancer cell lines | ||||
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