Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study)
Ahmed Abd El-Moeze, N., Mohamed Sayed, M., Medht Masoud, A., AbdAllah Mahmoud, S., Ismail Moustafa, W. (2021). Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study). EKB Journal Management System, 2(2), 250-261. doi: 10.21608/ejmr.2021.175727
Nadia Ahmed Abd El-Moeze; Marwa Mohamed Sayed; Amr Medht Masoud; Samira AbdAllah Mahmoud; Wesam Ismail Moustafa. "Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study)". EKB Journal Management System, 2, 2, 2021, 250-261. doi: 10.21608/ejmr.2021.175727
Ahmed Abd El-Moeze, N., Mohamed Sayed, M., Medht Masoud, A., AbdAllah Mahmoud, S., Ismail Moustafa, W. (2021). 'Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study)', EKB Journal Management System, 2(2), pp. 250-261. doi: 10.21608/ejmr.2021.175727
Ahmed Abd El-Moeze, N., Mohamed Sayed, M., Medht Masoud, A., AbdAllah Mahmoud, S., Ismail Moustafa, W. Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study). EKB Journal Management System, 2021; 2(2): 250-261. doi: 10.21608/ejmr.2021.175727

Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study)

Egyptian Journal of Medical Research
Article 17, Volume 2, Issue 2 - Serial Number 1, June 2021, Page 250-261  XML PDF (572.62 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2021.175727
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Authors
Nadia Ahmed Abd El-Moeze1; Marwa Mohamed Sayed1; Amr Medht Masoud2; Samira AbdAllah Mahmoud3; Wesam Ismail Moustafa1
1Pathology department, Faculty of medicine, Beni- Suef University, Beni-Suef, 62514, Egypt
2Urology department, Faculty of medicine, Beni- Suef University, Beni-Suef, 62514, Egypt
3Pathology department, Faculty of medicine, Cairo University, Cairo, 11865, Egypt
Abstract
The aim of this work is to evaluate the immunohistochemical expression of PD-L1 in tumor cells of urothelial bladder carcinoma. PD-L1 immunoexpression was assessed on 20 cases of radical cystectomy specimens using monoclonal rabbit anti- PD-L1 antibody.  Extent of membranous PD-L1 expression was assigned in each case. Tumor cells showing > 5% expression were considered positive. PD-L1was seen in 6 (30%) cases [1 case score +2 and 5 cases score +3], while 14(70%) cases were negative [7 cases score 0 and 7 cases score +1]. PD-L1 expression in tumor cells was insignificantly correlated with different available clinicopathological parameters such as sex, pathological stage, associatedbilharzial infestation, necrosis, perineural invasion and associated tumor infiltrating mononuclear cells (TIMCs), although PD-L1 positivity tend to predominate in advanced pathological stage of tumor (T3 and T4). These findings may have clinical implications for the management of patients with PD-L1 positive urothelial bladder carcinoma.
Keywords
PDL-1; UBC; Immunohistochemistry
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