Does Farnesoid X receptor (FXR) Have a Role in NAFLD Progression ?
Mahmoud, S., Sweed, D., Karman, E., Asaad, N., Holah, N. (2021). Does Farnesoid X receptor (FXR) Have a Role in NAFLD Progression ?. EKB Journal Management System, 84(1), 1703-1710. doi: 10.21608/ejhm.2021.175733
Shereen Fathy Mahmoud; Dina Sweed; Esraa Abdelrahman Karman; Nancy Youssef Asaad; Nanis Shawky Holah. "Does Farnesoid X receptor (FXR) Have a Role in NAFLD Progression ?". EKB Journal Management System, 84, 1, 2021, 1703-1710. doi: 10.21608/ejhm.2021.175733
Mahmoud, S., Sweed, D., Karman, E., Asaad, N., Holah, N. (2021). 'Does Farnesoid X receptor (FXR) Have a Role in NAFLD Progression ?', EKB Journal Management System, 84(1), pp. 1703-1710. doi: 10.21608/ejhm.2021.175733
Mahmoud, S., Sweed, D., Karman, E., Asaad, N., Holah, N. Does Farnesoid X receptor (FXR) Have a Role in NAFLD Progression ?. EKB Journal Management System, 2021; 84(1): 1703-1710. doi: 10.21608/ejhm.2021.175733

Does Farnesoid X receptor (FXR) Have a Role in NAFLD Progression ?

The Egyptian Journal of Hospital Medicine
Article 13, Volume 84, Issue 1, July 2021, Page 1703-1710  XML PDF (556.67 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.175733
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Authors
Shereen Fathy Mahmoud1; Dina Sweedorcid 1; Esraa Abdelrahman Karman email 2; Nancy Youssef Asaad1; Nanis Shawky Holah1
1Pathology Department, Faculty of Medicine Menofia University, Egypt
2pathology department, National Liver Institute, Menoufia University
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is the emerging cause of chronic liver disease. In addition, steatosis may lead to failure of obtaining sustained virological response after hepatitis C virus eradication. Therefore, there is a trend to identify effective strategies for managing hepatic steatosis. Farnesoid X receptor (FXR) agonists are reported to play a role in NAFLD treatment.
Objective: This study aimed to explore the immunohistochemical expression of FXR in NAFLD spectrum in association with the clinicopathological data.
Material and method: This was a retrospective study including 50 cases of NAFLD and 23 cases of normal liver. The NAFLD group was subdivided into 11 cases of NAFL (simple steatosis) and 39 cases of non-alcoholic steatohepatitis (NASH). Results: Hepatocyte FXR nuclear expression was significantly decreased in NASH group (P=0.001) with no significant decrease in NAFL group compared to normal liver (P=0.149). Bile duct FXR expression was significantly lower in NAFL group compared to normal liver (P= 0.009) to reach the lowest level in NASH group (P= 0.017). In NAFLD group, there was an inverse correlation between hepatocyte FXR nuclear expression and the ALT/AST ratio (r=-0.349 and P=0.013). However, hepatocyte FXR nuclear expression was significantly associated with moderate grade of steatosis and severe fibrosis (P= 0.044 and P= 0.033, respectively).
Conclusion: Hepatocyte FXR nuclear expression showed a stepwise decrease in its expression from normal to NASH passing with NAFL. Therefore, FXR has a protective role against NAFLD progression. Elevated liver enzymes could be used as a non-invasive method for monitoring FXR agonists' efficacy.
 
Keywords
ALT/AST ratio; FXR; NAFLD spectrum
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