Spectrophotometric Determination of Doxycycline Via Oxidation Reduction Reactions | ||||
| Egyptian Journal of Chemistry | ||||
| Article 48, Volume 64, Issue 11, November 2021, Page 6615-6621 PDF (373.71 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.77684.3791 | ||||
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| Authors | ||||
Firas Hassan Awad  1; Anmar Ghanim Taki2
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| 1Dept. of Dental Industry Techniques, Al-Qalam University College, Kirkuk, Iraq | ||||
| 2Dept. of Radiology & Sonar, Al-Noor University College, Mosul, Iraq | ||||
| Abstract | ||||
| Two sensitive methods have been proposed For spectrophotometric determination pure form of Doxycycline (Dox) and in its pharmaceutical preparation. The procedures based on the oxidation of the Doxycycline in acidic media by Fe(III). The results Fe(II) reacted with 1,10- phenanthroline in Method A, and the ferroin complex can measure at 510 nm versus the blank of reagent. While method B depends on the reaction of 2,2'-bipyridyl with the resulted Fe(II) to form a stable coloured complex with maximum 522 nm absorption against reagent blank. Beer’s law is applicable in the range of 0.1-9.00 μg/ml and 0.15-4.50 μg/ml concentration with molar absorption of 8.25×104 and 7.53×104 l.mol-1.cm-1 for method A and B, respectively. For both processes, the mean percentage of recoveries is 99.9 per cent and 98.5% respectively. The suggested methods are free from interferences from common excipients. The proposed methods compared favourably with the official and other spectrophotometric methods. | ||||
| Keywords | ||||
| 1,10-Phenanthroline; 2,2'-Bipyridyl; Pharmaceutical analysis; Spectrophotometric | ||||
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