Field efficacy of concentrated inactivated bovine respiratory viral disease vaccine in cattle
El-Bagoury, G., Mansour, M., Kassem, I. (2019). Field efficacy of concentrated inactivated bovine respiratory viral disease vaccine in cattle. EKB Journal Management System, 36(1), 437-441. doi: 10.21608/bvmj.2019.176063
G.F. El-Bagoury; Manal. A. Mansour; Iman. K.A. Kassem. "Field efficacy of concentrated inactivated bovine respiratory viral disease vaccine in cattle". EKB Journal Management System, 36, 1, 2019, 437-441. doi: 10.21608/bvmj.2019.176063
El-Bagoury, G., Mansour, M., Kassem, I. (2019). 'Field efficacy of concentrated inactivated bovine respiratory viral disease vaccine in cattle', EKB Journal Management System, 36(1), pp. 437-441. doi: 10.21608/bvmj.2019.176063
El-Bagoury, G., Mansour, M., Kassem, I. Field efficacy of concentrated inactivated bovine respiratory viral disease vaccine in cattle. EKB Journal Management System, 2019; 36(1): 437-441. doi: 10.21608/bvmj.2019.176063

Field efficacy of concentrated inactivated bovine respiratory viral disease vaccine in cattle

Benha Veterinary Medical Journal
Article 46, Volume 36, Issue 1, March 2019, Page 437-441  XML PDF (932.05 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2019.176063
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Authors
G.F. El-Bagoury1; Manal. A. Mansour2; Iman. K.A. Kassem2
1Department of Virology, Faculty of Veterinary Medicine, Benha University
2Veterinary serum and vaccine research institute, Abbassia, Cairo
Abstract
This work was carried out to evaluate the efficacy of locally prepared concentrated combined inactivated vaccines comprising BVD, BOHV-1, PI-3 and BRS viruses adjuvanted with aluminum hydroxide gel or montanide oil ISA206 under field condition.
The prepared vaccines adjuvanted aluminum hydroxide gel or montanide oil ISA206 were administered to 6-9-month-old seronegative calves through intramuscular (IM) route at different doses 2.5ml and 3ml respectively. The calves were boostered after two weeks and sera were collected two weeks after vaccination then monthly for 6th month postvaccination. The induced antibodies were tested using Serum Neutralization Test (SNT). Our results revealed that, the concentrated vaccine has a significant effect on serum antibody levels by the 2nd wpv till 6 mpv. Moreover, the concentrated vaccine adjuvanted by montanide oil showed prolongation of antibody in comparison to the adjuvanted with aluminum hydroxide gel.
 
Keywords
Inactivated concentrated vaccine; Polyethylene Glycol; SNT
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