Phytochemical Investigation and Differential Effects of Cestrum elegans Isolated Compounds as Antimicrobial and Virucidal against Hepatitis A Virus | ||||
| Egyptian Journal of Chemistry | ||||
| Article 50, Volume 64, Issue 7, July 2021, Page 3729-3738 PDF (579.56 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.71934.3581 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sami Mohamed Nasr 1; Nehal M Elwan2; Mona Abdel-Motagaly1; Abdel-Wanes Anter Abdel-Aziz  1; Mosad Ghareeb3
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| 1Theodor Bilharz Research Institute | ||||
| 2chemistry department, faculty of science, cairo university | ||||
| 3Medicinal Chemistry, Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt | ||||
| Abstract | ||||
| A new steroidal saponin, named as (25R)-6α-[(β-D-glucopyranosyl) oxy]-5α-spirostan-3β-yl β-D-glucopyranosyl (1''→3')-O-β-D-glucopyranosid (2) was isolated from the flowers of Cestrum elegans. In addition, a known steroidal saponin (1), a flavonoid compound (3) along with a triterpene saponin (4) were isolated for the first time in genus Cestrum and identified based on their chromatographic properties, chemical and spectral data (HR-ESI-MS, 1H, 13C NMR, 1H-1H COSY, HSQC, and HMBC). The four compounds are characterized by different effects against Gram positive, Gram negative bacteria, antifungal and antiviral activities. The maximum non-toxic concentration (MNTC) on vero cell line was 1.56 µg/mL for all compounds. While compound 1 and 3 showed the highest biological activities against hepatitis A virus possess 34.3% and 25% antiviral activity respectively.. | ||||
| Keywords | ||||
| Antiviral; Antimicrobial; Cestrum elegans; Cytotoxicity; Steroidal saponin | ||||
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