The Toxicological effects of fenitrothion and vitamin E as antioxidant agent on the biochemical, cytogenetic and histopathological parameters of white rats
Abdel Reheim, F., Ragab, A., Hammam, F., Hamdy, H. (2008). The Toxicological effects of fenitrothion and vitamin E as antioxidant agent on the biochemical, cytogenetic and histopathological parameters of white rats. EKB Journal Management System, 33(1), 604-421. doi: 10.21608/ejhm.2008.17624
Fouad Abdel Reheim; Awad Abbas Ragab; Fatma.M. Hammam; Hossam El-Din Hamdy. "The Toxicological effects of fenitrothion and vitamin E as antioxidant agent on the biochemical, cytogenetic and histopathological parameters of white rats". EKB Journal Management System, 33, 1, 2008, 604-421. doi: 10.21608/ejhm.2008.17624
Abdel Reheim, F., Ragab, A., Hammam, F., Hamdy, H. (2008). 'The Toxicological effects of fenitrothion and vitamin E as antioxidant agent on the biochemical, cytogenetic and histopathological parameters of white rats', EKB Journal Management System, 33(1), pp. 604-421. doi: 10.21608/ejhm.2008.17624
Abdel Reheim, F., Ragab, A., Hammam, F., Hamdy, H. The Toxicological effects of fenitrothion and vitamin E as antioxidant agent on the biochemical, cytogenetic and histopathological parameters of white rats. EKB Journal Management System, 2008; 33(1): 604-421. doi: 10.21608/ejhm.2008.17624

The Toxicological effects of fenitrothion and vitamin E as antioxidant agent on the biochemical, cytogenetic and histopathological parameters of white rats

The Egyptian Journal of Hospital Medicine
Article 13, Volume 33, Issue 1, October 2008, Page 604-421  XML PDF (1.02 MB)
Document Type: Original Article
DOI: 10.21608/ejhm.2008.17624
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Authors
Fouad Abdel Reheim1; Awad Abbas Ragab1; Fatma.M. Hammam2; Hossam El-Din Hamdy2
1Department of Biochemistry, Faculty of Agriculture, Cairo University
2Department of Mammalian Toxicology, Central Agricultural Pesticides Laboratory, Agricultural Research Centre.
Abstract
Background: The use of pesticides has been increased considerably nowadays compared to the past. The hazards of using such chemical compounds have been accentuated by the sharp rise of their use in agriculture, industry, by householders and governments. Exposure to organophosphorus insecticides (OPI) in agriculture is one of the occupational hazards. Fenitrothion is one of the most important OPI. The major object of the present study was to evaluated the toxicological (biochemical, mutagenic and histopathological) effects of tested insecticide "fenitrothion" alone or combined to vitamin E as an antioxidant agent to decrease their toxic effect.
Material and Method male albino rats were tested orally for 30 days, three doses of fenitrothion were used in absence and presence of vitamin E (1/20, 1/40 and 1/80 LD50).
Results the obtained data showed marked changes in biochemical parameter, highly inhibition of AchE activity; highly significant increase in the frequency of micronucleus (PCEM) in rat bone marrow cells at all doses of fenitrothion alone or combined to vitamin compared to control group. Also, the histopathological examination of liver and kidney tissues revealed high alternation in these tissues corresponding to biochemical changes.
Conclusion From these results we concluded that fenitrothion exert biochemical, mutagenic and histopathological effects in white rats. In addition, vitamin E has mild role in alleviating these toxicological effects.
 
Keywords
Organophosphorus; fenitrothion; antioxidant agent; micronucleus
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