Effect of Pomegranate Peel Extract Alternatives to Oxytetracycline on Growth Peformance and Physiological Homeostasis in Rabbits
Mohammed, A., IMBABI, T., radwan, A., El-sayed, A. (2021). Effect of Pomegranate Peel Extract Alternatives to Oxytetracycline on Growth Peformance and Physiological Homeostasis in Rabbits. EKB Journal Management System, 59(1), 31-36. doi: 10.21608/assjm.2021.176385
Asmaa Maher Mohammed; THARWAT ALSEID IMBABI; ahmed abou elsaoud radwan; abdelkarim Ibrahim El-sayed. "Effect of Pomegranate Peel Extract Alternatives to Oxytetracycline on Growth Peformance and Physiological Homeostasis in Rabbits". EKB Journal Management System, 59, 1, 2021, 31-36. doi: 10.21608/assjm.2021.176385
Mohammed, A., IMBABI, T., radwan, A., El-sayed, A. (2021). 'Effect of Pomegranate Peel Extract Alternatives to Oxytetracycline on Growth Peformance and Physiological Homeostasis in Rabbits', EKB Journal Management System, 59(1), pp. 31-36. doi: 10.21608/assjm.2021.176385
Mohammed, A., IMBABI, T., radwan, A., El-sayed, A. Effect of Pomegranate Peel Extract Alternatives to Oxytetracycline on Growth Peformance and Physiological Homeostasis in Rabbits. EKB Journal Management System, 2021; 59(1): 31-36. doi: 10.21608/assjm.2021.176385

Effect of Pomegranate Peel Extract Alternatives to Oxytetracycline on Growth Peformance and Physiological Homeostasis in Rabbits

Annals of Agricultural Science, Moshtohor
Article 4, Volume 59, Issue 1, March 2021, Page 31-36  XML PDF (444.76 K)
Document Type: Original Article
DOI: 10.21608/assjm.2021.176385
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Authors
Asmaa Maher Mohammed email 1; THARWAT ALSEID IMBABI email orcid 2; ahmed abou elsaoud radwan email 3; abdelkarim Ibrahim El-sayed email 4
1Animal production, Faculty of Agriculture, Benha University
2DEPARTMENT OF ANIMAL PRODUCTION
3animal production department, faculty of agriculture, benha university
4animal production department , Benha University
Abstract
The current study focused on evaluation of pomegranate peel extract (PPE) and the oxytetracycline as antioxidant and antiapoptotic potentialities on New Zealand White rabbits (NZW) performance, physiological homeostasis, hemato-biochemical indices and stabilized DNA structure resembling in 8-hydroxy-2-deoxyguanosine (8OH2dG) level. For this purpose, four groups (each one compromise of 6 animals) of weaned NZW rabbits aged four weeks were randomly divided as follows: The 1st group preserved as normal control (C) treated with tap water; 2nd group (OXY) treated with daily oral dose of Oxytetracycline 200 mg/kg BW/day; 3rdgroup (PPE) treated with daily oral dose of 130 mg/kg BW/day of PPE; 4th group OXY + PPE treated with daily oral dose of 100 mg/kg BW/day of OXY + 65 mg/kg BW/day of PPE. The experiment lasted for 8 weeks. Concerning growth parameters, results showed that treatment with PPE and its combination with OXY enhanced body weight and ameliorate the negative effect on liver and kidney function with minimal side effects. In addition PPE elevate antioxidant parameters. However, OXY decreases the growth parameters (live body weight and body weight gain), total protein, albumin, globulin and A/G ratio levels and induces markedly increases in AST, ALT, creatinine, cortisol, and liver 8OH2dG concentrations. In conclusion, present study aimed to investigate the common side effects of oxytetracycline when compared with natural pomegranate peel extract and suggests that PPE and its combination with OXY at half dose of each ameliorate side effects of oxytetracycline, accelerate body weight and normalize physiological homeostasis. 
Keywords
Pomegranate peel extract; Oxytetracycline; antioxidants; New Zealand White rabbits
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