Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomiasis among Egyptian patients | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 6, Volume 30, Issue 1, January 2008, Page 62-69 PDF (1.43 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhm.2008.17653 | ||||
View on SCiNiTO | ||||
Authors | ||||
Maghraby A.S1; Samia A. Ahmed2; Ayman M. Metwally3; Khalid H4 | ||||
1Therapeutic Chemistry Department National Research Center, Dokki, Cairo. Infectious Diseases and Immunology group, Center of Excellence for Advanced Studies | ||||
2Therapeutic Chemistry Department National Research Center, Dokki, Cairo. | ||||
3Technology of Medical Laboratory Department, College of Applied Medical Sciences, Misr University For Science and Technology, 6th of October, Egyp | ||||
4National Cancer Institute, Cairo | ||||
Abstract | ||||
Introduction: Schistosomiasis is considered as a widespread problem that affects Egyptians at different ages (WHO, 1993). It is well known that the high incidence of bladder carcinoma in schistosomal patients also represents a great risk to Egyptian society. Objective: This study represents a survey on the changes which took place in Alpha- Fetoprotein (AFP) levels as a differential marker among Egyptian patients suffering from urinary bilharzial infection and bladder cancer. Methodology: A partial study was carried out on four post-operative patients and followed up for sixty three days after chemotherapeutic treatment using immunoenzymatic mediated assay. Results: It was found that bladder cancer leads to obvious significant increase in AFP levels, while schistosomal infection causes a non-significant decrease as compared to healthy control. Although the combination between schistosomal infection and cancer leads to a significant decrease in AFP level compared to non bilharzial cancer cases, there was no significant correlation with healthy cases. Conclusion: It should be pointed out that the somewhat constant level of AFP in the sera of all patients was due to chemotherapeutic treatment. Also, it can be noticed that there is a significant positive correlation with progress of cancer grades. | ||||
Keywords | ||||
alpha-fetoprotein; schistosomal infection; urinary bilharzial infection and bladder cancer | ||||
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