Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomiasis among Egyptian patients
A.S, M., Ahmed, S., Metwally, A., H, K. (2008). Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomiasis among Egyptian patients. EKB Journal Management System, 30(1), 62-69. doi: 10.21608/ejhm.2008.17653
Maghraby A.S; Samia A. Ahmed; Ayman M. Metwally; Khalid H. "Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomiasis among Egyptian patients". EKB Journal Management System, 30, 1, 2008, 62-69. doi: 10.21608/ejhm.2008.17653
A.S, M., Ahmed, S., Metwally, A., H, K. (2008). 'Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomiasis among Egyptian patients', EKB Journal Management System, 30(1), pp. 62-69. doi: 10.21608/ejhm.2008.17653
A.S, M., Ahmed, S., Metwally, A., H, K. Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomiasis among Egyptian patients. EKB Journal Management System, 2008; 30(1): 62-69. doi: 10.21608/ejhm.2008.17653

Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomiasis among Egyptian patients

The Egyptian Journal of Hospital Medicine
Article 6, Volume 30, Issue 1, January 2008, Page 62-69  XML PDF (1.43 MB)
Document Type: Original Article
DOI: 10.21608/ejhm.2008.17653
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Authors
Maghraby A.S1; Samia A. Ahmed2; Ayman M. Metwally3; Khalid H4
1Therapeutic Chemistry Department National Research Center, Dokki, Cairo. Infectious Diseases and Immunology group, Center of Excellence for Advanced Studies
2Therapeutic Chemistry Department National Research Center, Dokki, Cairo.
3Technology of Medical Laboratory Department, College of Applied Medical Sciences, Misr University For Science and Technology, 6th of October, Egyp
4National Cancer Institute, Cairo
Abstract
Introduction: Schistosomiasis is considered as a widespread problem that affects Egyptians at different ages (WHO, 1993). It is well known that the high incidence of bladder carcinoma in schistosomal patients also represents a great risk to Egyptian society.
Objective: This study represents a survey on the changes which took place in Alpha- Fetoprotein (AFP) levels as a differential marker among Egyptian patients suffering from urinary bilharzial infection and bladder cancer.
Methodology: A partial study was carried out on four post-operative patients and followed up for sixty three days after chemotherapeutic treatment using immunoenzymatic mediated assay.
Results: It was found that bladder cancer leads to obvious significant increase in AFP levels, while schistosomal infection causes a non-significant decrease as compared to healthy control. Although the combination between schistosomal infection and cancer leads to a significant decrease in AFP level compared to non bilharzial cancer cases, there was no significant correlation with healthy cases.
Conclusion: It should be pointed out that the somewhat constant level of AFP in the sera of all patients was due to chemotherapeutic treatment. Also, it can be noticed that there is a significant positive correlation with progress of cancer grades.
 
Keywords
alpha-fetoprotein; schistosomal infection; urinary bilharzial infection and bladder cancer
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