Study of Red Blood Cell Indices and Biochemical Parameters of Mineral Bone Disorders in Hemodialysis Patients | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 21, Volume 84, Issue 1, July 2021, Pages 1765-1771 PDF (499.96 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.176583 | ||
| Authors | ||
| Alhoussein Alsayed Abdelaal* 1; Alshabrawy M. Abdelnabi2 | ||
| 1Zagazig university/Sharkia/Egypt | ||
| 2Department of Internal Medicine, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Background: Chronic kidney disease (CKD) is a worldwide public health problem and a major cause of suffering and having a reduced quality of life for those affected. Objective: We aimed to study the changes in red blood cell indices and mineral bone metabolism in hemodialysis patients and to explore the correlation between these studied parameters. Patients and Methods: This is a case control study included 55 adult patients with end stage renal disease on maintenance hemodialysis as well as 55 healthy individuals as a control group. All participants were subjected to laboratory investigations included complete blood count and serum levels of creatinine, urea, total calcium, albumin, phosphate and intact parathyroid hormone (iPTH). Results: Our study showed thathemoglobin (Hb), hematocrit and red blood cell count were significantly reduced in the hemodialysis patients (P<0.001 for all). Regarding mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, no significant differences were found between the hemodialysis patients and the control group (P= 0.362, 0.116, 0.22, respectively). In the hemodialysis group, the albumin-corrected serum calcium level was significantly lower while the serum phosphate and iPTH levels were significantly higher compared to the control group (P<0.001 for all). Hb was inversely correlated with serum iPTH (r=-0.359, P=0.007) and serum phosphate (r=-0.570, P<0.001) in the hemodialysis group and was inversely correlated with serum phosphate (r=-0.495, P<0.001) in the control group. Conclusion: Hemodialysis patients are at high risk of anemia, hypocalcemia, hyperphosphatemia and hyperparathyroidism. In hemodialysis patients, an association was found between anemia and each of hyperphosphatemia and hyperparathyroidism. | ||
| Keywords | ||
| Anemia; Chronic kidney disease; Hemodialysis; Mineral bone disorder | ||
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