The role of black seed and/ or bees honey in modulating the heart disorder induced by food additives in male rats.
El-Kholy, W., Hassan, H., Nour, S. (2007). The role of black seed and/ or bees honey in modulating the heart disorder induced by food additives in male rats.. EKB Journal Management System, 28(1), 327-341. doi: 10.21608/ejhm.2007.17664
Wafaa M. El-Kholy; Hanaa A. Hassan; Samar E. Nour. "The role of black seed and/ or bees honey in modulating the heart disorder induced by food additives in male rats.". EKB Journal Management System, 28, 1, 2007, 327-341. doi: 10.21608/ejhm.2007.17664
El-Kholy, W., Hassan, H., Nour, S. (2007). 'The role of black seed and/ or bees honey in modulating the heart disorder induced by food additives in male rats.', EKB Journal Management System, 28(1), pp. 327-341. doi: 10.21608/ejhm.2007.17664
El-Kholy, W., Hassan, H., Nour, S. The role of black seed and/ or bees honey in modulating the heart disorder induced by food additives in male rats.. EKB Journal Management System, 2007; 28(1): 327-341. doi: 10.21608/ejhm.2007.17664

The role of black seed and/ or bees honey in modulating the heart disorder induced by food additives in male rats.

The Egyptian Journal of Hospital Medicine
Article 3, Volume 28, Issue 1, July 2007, Page 327-341  XML PDF (469.59 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2007.17664
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Authors
Wafaa M. El-Kholy; Hanaa A. Hassan; Samar E. Nour
Zoology Department, Faculty of Science, Mansoura University
Abstract
Background: The present study aimed to throw the light on the potential hazards of some food additives whether preservatives such as sodium nitrite or colors as sunset yellow on the heart disorders through their own effect or the interaction between them. The study also, investigated the possible protective role of black seed and/ or bees honey against such risks.
Results: Herein, the mentioned food additives caused significant elevations in serum and cardiac total lipids (TL), total cholesterol (TC), triglycerides (TG) and phospholipids (PL) levels as well as serum LDL-c, VLDL-c levels and LDL-c/HDL-c ratio. Meanwhile, significant decrements were shown in serum HDL-c level and HDL-c/TC ratio. Additionally, creatine kinase (CK) and aspartate transferase (AST) enzymes activity were increased significantly in serum and cardiac tissue.
Moreover, oxidative stress markers; lipid peroxidation product (MDA) and protein carbonyl group (PC) were increased significantly in the cardiac tissue. Regarding, antioxidants; glutathione (GSH) content, glutathione -S -transferase (GST) and catalase (CAT) enzymes activity were decreased significantly in the cardiac tissue.
Conclusion: However, the use of black seed and/ or bees honey ameliorated the disturbances observed indicating remarkable protection against the toxic effects of these food additives on the heart and offers more safety. Overall, here with the most pronounced effect was achieved by the combined treatment. In addition, the treatment by bees honey was more effective than black seed.
 
Keywords
food additives; sunset yellow; Sodium Nitrite; Rats
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