The effect of L-Carnitine on Sodium Valproate-Induced Physiological Disturbances in Rats | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 5, Volume 28, Issue 1, July 2007, Page 347-354 PDF (266.21 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2007.17666 | ||||
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| Authors | ||||
| Fahmy G. Elsaid1; Fawzya E. Zeghiebr2 | ||||
| 1Zoology Department, Faculty of Science, Mansoura University, Egypt | ||||
| 2Zoology Department, Faculty of Science, Mansoura University, Egypt. | ||||
| Abstract | ||||
| Background: Chronic treatment with sodium valproate (VPA) can lead to elevation of specific oxidative metabolites that associated with the drug’s toxicity. Results: Valproate exposure leads to an increase in reactive oxygen species (ROS). The levels of lipid peroxidation (malondialdehyde), and lipid profile variables (cholesterol, phospholipids, triglycerides and free fatty acids) were significantly increased (p<0.001) in orally administrated rats with sodium valproate at 400 mg/kg body weight/day. Also the deflection in the activities of catalase (CAT), lactate dehydrogenase (LDH) and Na,K-ATPase was registered where CAT, LDH and Na-K, ATPase activities were decreased (p<0.001) in rats under VPA treatment compared to the controls. These changes were more pronounced in valproate 60 days treated group than in valproate 30 days treated group. Oral administration of l-carnitine (L-CAR) at 300 mg/kg b. w. /day showed alleviation in all metabolic and physiologic changes in rats treated with sodium valproate. L-CAR supplementation might be recommended for human especially for epileptic persons subjected for long term to sodium valproate treatment. | ||||
| Keywords | ||||
| Sodium valproate; L-carnitine; Epilepsy; Lipid profile; Malondialdehyde; catalase; Lactate dehydrogenase and Na; K- ATPase activities; muscle; Brain; bone and liver | ||||
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