Study on the Oxidant and Antioxidant Status in Vitiligo Patients
Shabaka, F., EL- Sayed, S., Abdel- Badea, G., Mahmoud, M., Hossni, R. (2007). Study on the Oxidant and Antioxidant Status in Vitiligo Patients. EKB Journal Management System, 28(1), 429-438. doi: 10.21608/ejhm.2007.17672
Fatma Hassan Shabaka; Sawsan Khalifa EL- Sayed; Gada Abdel- Badea; Manal Mohsen Mahmoud; Rania Mahmoud Hossni. "Study on the Oxidant and Antioxidant Status in Vitiligo Patients". EKB Journal Management System, 28, 1, 2007, 429-438. doi: 10.21608/ejhm.2007.17672
Shabaka, F., EL- Sayed, S., Abdel- Badea, G., Mahmoud, M., Hossni, R. (2007). 'Study on the Oxidant and Antioxidant Status in Vitiligo Patients', EKB Journal Management System, 28(1), pp. 429-438. doi: 10.21608/ejhm.2007.17672
Shabaka, F., EL- Sayed, S., Abdel- Badea, G., Mahmoud, M., Hossni, R. Study on the Oxidant and Antioxidant Status in Vitiligo Patients. EKB Journal Management System, 2007; 28(1): 429-438. doi: 10.21608/ejhm.2007.17672

Study on the Oxidant and Antioxidant Status in Vitiligo Patients

The Egyptian Journal of Hospital Medicine
Article 11, Volume 28, Issue 1, July 2007, Page 429-438  XML PDF (344.47 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2007.17672
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Authors
Fatma Hassan Shabaka1; Sawsan Khalifa EL- Sayed1; Gada Abdel- Badea1; Manal Mohsen Mahmoud2; Rania Mahmoud Hossni3
1Department of Dermatology and Venereology, AI- Azhar University for Girl
2Prof. of Biochem. Faculty of Medicine Cairo Univ.
3M.B., B. ch.
Abstract
Backgrounds: The aetiology of vitiligo is still unknown. Several hypotheses have been proposed to explain vitiligo: genetic neural, immunological, self destructive, convergence hypothesis and oxidative stress hypothesis
The current study is concerned with the oxidative stress hypothesis and how oxidants and antioxidants affect the pathogenesis of vitiligo. So, our aim is to determine the role of malondialdehyde and glutathione in the pathogenesis of vitiligo. The amount of malondialdehyde (oxidant) and glutathione (antioxidant) were measured in serum and in skin tissue in 30 vitiligo cases and 20 healthy controls
Results: The study showed significant changes between patients and controls in glutathione level in blood and tissue samples. Also there were significant changes between




patients and controls in malondialdehyde glutathione and malondialdehyde play a role
 
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