Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients
Elnaggar, Y., Tolba, M., Halawa, M., El-Demerdash, E. (2021). Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients. EKB Journal Management System, 5(1), 1-15. doi: 10.21608/aps.2021.58439.1051
Yasmin Elnaggar; Mai Tolba; Mohamed Halawa; Ebtehal El-Demerdash. "Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients". EKB Journal Management System, 5, 1, 2021, 1-15. doi: 10.21608/aps.2021.58439.1051
Elnaggar, Y., Tolba, M., Halawa, M., El-Demerdash, E. (2021). 'Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients', EKB Journal Management System, 5(1), pp. 1-15. doi: 10.21608/aps.2021.58439.1051
Elnaggar, Y., Tolba, M., Halawa, M., El-Demerdash, E. Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients. EKB Journal Management System, 2021; 5(1): 1-15. doi: 10.21608/aps.2021.58439.1051

Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients

Archives of Pharmaceutical Sciences Ain Shams University
Article 1, Volume 5, Issue 1, June 2021, Page 1-15  XML PDF (782.83 K)
Document Type: Original Article
DOI: 10.21608/aps.2021.58439.1051
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Authors
Yasmin Elnaggar email 1; Mai Tolba2; Mohamed Halawa3; Ebtehal El-Demerdash2
1Clinical pharmacy, Ain Shams University Specialised Hospital, Cairo 11588, Egypt
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
3Endocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: Diabetes mellitus (DM) is a group of metabolic disorders Characterized by chronic hyperglycaemic condition resulting from defects in insulin secretion, insulin action or both. Type2 Diabetes Mellitus (T2DM) is the predominant form of diabetes and represent 90% of all cases of DM. Studies show that vitamin D (VD) has an important role in modifying the risk of T2DM, especially among insulin resistant diabetic patients. Recently a novel association between insulin resistance and vitamin D deficiency has been proposed. Aim: In the current research we investigate the association between hypovitaminosis D and T2DM. Also we will study the effect of vitamin D supplementation on glycemic status, oxidative stress status and inflammatory markers in T2DM patients. Methods and patients: forty T2DM patients with hypovitaminosis D were assessed for glycemic, inflammatory and antioxidants parameters. After 6 months of VD supplementation for the intervention group of patients (n=20), there was significant improvement in VD level, Homeostatic model assessment of insulin resistance (HOMA - IR), Fasting blood glucose (FBG), glycated haemoglobin (HbAIC), serum insulin, interleukin 6 (IL-6), tumor necrosis factor -α (TNF-α), total antioxidant capacity (TAC) and malondialdehyde (MDA). Conclusion: Vitamin D supplementation has a promising effect on the treatment of Type 2 Diabetes as there is a significant improvement in glycemic , inflammatory and oxidative parameters in Type 2 Diabetes mellitus patients
Keywords
Type 2 Diabetes Mellitus; cytokines; oxidative stress; Vitamin D; insulin resistance
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