Genotoxicity of paracetamol on the germ cells of Drosophilla melanogaster | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 3, Volume 29, Issue 1, October 2007, Page 486-491 PDF (277.62 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2007.17695 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Saleha Y. M. alakilli | ||||
| Department of Biology, Faculty of science, King Abdelaziz University, Saudi Arabia | ||||
| Abstract | ||||
| Paracetamol is a common analgesic and antipyretic drug. The aim of the present study is to determine the potential genetic effects of Paracetamol in Drosophilla melanogaster using two methods: Sex Linked Recessive Lethals (SLRL) test and effect of Paracetamol on enzyme activity using spectrophotometric analysis. Three concentrations of drug were used (5, 10, and 20 mM). The results reveal significant differences in S.L.R.L, except spermatozoa stages showed insignificant increases when the data of the four broods were considered all together in three treatments. Meanwhile, Paracetamol showed a genotoxic effects in the three categories of the two generations of S.L.R.L, F1 heterozygous females, F2 bar eye females and F2 wild type males on the genetic back ground of Cholinesterase in all treatments. | ||||
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