Effect of melatonin on gamma radiation-induced brain damage in rats | ||||
| Journal of Environmental Sciences. Mansoura University | ||||
| Article 1, Volume 48, Issue 4, December 2019, Page 144-148 PDF (381.1 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/joese.2019.177052 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Sara Ghazala; Sameh Shabana; Mohamed A. Elmisiry | ||||
| Zoology dept., faculty of Science, Mansoura University, Egypt | ||||
| Abstract | ||||
| Exposure to ionizing radiation produced radiation sickness that is a collection of short- and long-term complications. The aim of the present study was to investigate the potential neuroprotective effect of melatonin (MLT) on radiation-induced cell death and hippocampus injury. Rats were divided into seven groups namely control, two melatonin treated groups (MLT-1 and MLT-7) treated with melatonin for one and 7 days, two irradiated groups (Rad-1 and Rad7) sacrificed after one and seven days respectively, and two melatonin treated and irradiated groups (MLT-Rad-1 and MLT Rad-7) sacrificed after one- and seven-days post irradiation. Control rats did not receive any treatment. Melatonin treated groups were injected melatonin at a dose of 10mg/kg. Rats in the Irradiated groups, rats were subjected to a single dose of 4Gy γ-radiation from cobalt-60 source. The present results showed that melatonin protected against body weight loss, nestin up-regulation and protected the histological structure of the hippocampus against irradiation. This will enable to the development of radio-preventive strategies for human under radiotherapy as well as occupational and professional exposure to ionizing radiation. | ||||
| Keywords | ||||
| Melatonin; Radiation; Hippocampus | ||||
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