Prevalence and Risk Factors of Helicobacter Pylori Recurrence in Egyptian Patients with Liver Cirrhosis
Hamed, M., Bassiony, M., Mohamed, A. (2021). Prevalence and Risk Factors of Helicobacter Pylori Recurrence in Egyptian Patients with Liver Cirrhosis. EKB Journal Management System, 84(1), 1791-1794. doi: 10.21608/ejhm.2021.177254
Mohamed G. Hamed; Mohamed Bassiony; Ayman F. Elsayed Mohamed. "Prevalence and Risk Factors of Helicobacter Pylori Recurrence in Egyptian Patients with Liver Cirrhosis". EKB Journal Management System, 84, 1, 2021, 1791-1794. doi: 10.21608/ejhm.2021.177254
Hamed, M., Bassiony, M., Mohamed, A. (2021). 'Prevalence and Risk Factors of Helicobacter Pylori Recurrence in Egyptian Patients with Liver Cirrhosis', EKB Journal Management System, 84(1), pp. 1791-1794. doi: 10.21608/ejhm.2021.177254
Hamed, M., Bassiony, M., Mohamed, A. Prevalence and Risk Factors of Helicobacter Pylori Recurrence in Egyptian Patients with Liver Cirrhosis. EKB Journal Management System, 2021; 84(1): 1791-1794. doi: 10.21608/ejhm.2021.177254

Prevalence and Risk Factors of Helicobacter Pylori Recurrence in Egyptian Patients with Liver Cirrhosis

The Egyptian Journal of Hospital Medicine
Article 25, Volume 84, Issue 1, July 2021, Page 1791-1794  XML PDF (537.18 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.177254
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Authors
Mohamed G. Hamed1; Mohamed Bassiony2; Ayman F. Elsayed Mohamed3
1Internal Medicine Department, Faculty of Medicine, Zagazig University,Egy
2Internal medicine department, Faculty of medicine, Zagazig university, Zagazig, Egypt
3Internal Medicine Department, Faculty of Medicine, Zagazig University,Egypt
Abstract
Background: Helicobacter pylori (H. pylori) is a worldwide gastrointestinal infection. It is a common risk factor for peptic ulcer disease (PUD), chronic gastritis, and stomach cancer. In patients with cirrhosis, there is a significant association between H. pylori infection and severity of gastropathy due to portal hypertension, chronic stomach upset, frequent upper gastrointestinal bleeding as well as hepatic encephalopathy.
Objective: To assess the rate and risk factors of recurrence of H. pylori infection in Egyptian patients with liver cirrhosis after successful eradication therapy. Patients and methods: This study included 500 liver cirrhosis patients who were tested for H. pylori infection. Patients with positive H. pylori infection received proton pump inhibitors (PPI)-based treatment regimen. Successful eradication therapy was assessed 4-8 weeks and repeated over one year after end of treatment using urea breath test (UBT) and stool antigen test (SAT).
Results: The prevalence of H. pylori infection in cirrhotic patients was 58%. There were significantly higher serum levels of ammonia and C-reactive protein (CRP) in H. pylori positive patients as well as significantly more gastritis in endoscopy findings in comparison with H. pylori-negative patients. H. pylori recurrence after successful eradication therapy was observed in 22.1% patients of H. pylori-positive cirrhotic patients. Multivariate analysis showed that higher serum ammonia level & receiving multiple treatment courses to achieve H. pylori eradication were independent risk factors for H. pylori recurrence in cirrhotic patients.
Conclusion: H. pylori infection is prevalent in liver cirrhosis patients with a significant recurrence rate after eradication therapy. High serum ammonia and the need for multiple treatment courses are risk factors for recurrence.
Keywords
Helicobacter pylori; Liver cirrhosis; Eradication therapy; Hepatitis C; Ammonia level; Bacterial resistance
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