Synthesis, Characterization and Biological Evaluation of Benzimidazole and Benzindazole Derivatives as Anti-hypertensive Agents
Sethy, S., Mandal, S., Ewies, E., Dhiman, N., Garg, A. (2021). Synthesis, Characterization and Biological Evaluation of Benzimidazole and Benzindazole Derivatives as Anti-hypertensive Agents. EKB Journal Management System, 64(7), 3659-3664. doi: 10.21608/ejchem.2021.79840.3931
Silky Sethy; Sudip Kumar Mandal; Ewies Fawzy Ewies; Neerupma Dhiman; Arun Garg. "Synthesis, Characterization and Biological Evaluation of Benzimidazole and Benzindazole Derivatives as Anti-hypertensive Agents". EKB Journal Management System, 64, 7, 2021, 3659-3664. doi: 10.21608/ejchem.2021.79840.3931
Sethy, S., Mandal, S., Ewies, E., Dhiman, N., Garg, A. (2021). 'Synthesis, Characterization and Biological Evaluation of Benzimidazole and Benzindazole Derivatives as Anti-hypertensive Agents', EKB Journal Management System, 64(7), pp. 3659-3664. doi: 10.21608/ejchem.2021.79840.3931
Sethy, S., Mandal, S., Ewies, E., Dhiman, N., Garg, A. Synthesis, Characterization and Biological Evaluation of Benzimidazole and Benzindazole Derivatives as Anti-hypertensive Agents. EKB Journal Management System, 2021; 64(7): 3659-3664. doi: 10.21608/ejchem.2021.79840.3931

Synthesis, Characterization and Biological Evaluation of Benzimidazole and Benzindazole Derivatives as Anti-hypertensive Agents

Egyptian Journal of Chemistry
Article 42, Volume 64, Issue 7, July 2021, Page 3659-3664  XML PDF (532.78 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.79840.3931
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Authors
Silky Sethy1; Sudip Kumar Mandalorcid 2; Ewies Fawzy Ewiesorcid 3; Neerupma Dhiman email 4; Arun Garg1
1SMAS, KR Mangalam University, Gurugram, Haryana
2Dr. B. C. Roy College of Pharmacy and A.H.S., Durgapur-713206, West Bengal, India
3Organometallic and Organometalloid Chemistry, Chemical Industries Division, National Research Centre
4Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh-201303, India
Abstract
A substituted benzimidazole and benzindazole derivatives had been synthesized having antihypertensive activity through antagonizing the angiotensin II (Ang II) receptors. The in vivo antihypertensive activity of the compounds was done with acute renal hypertension model. Two compounds TG 1 and TG 3 were found to have antihypertensive activity comparable to Telmisartan which is a prototype for Angiotensin II receptor antagonists class of drugs.In an antihypertensive study the compounds TG 1, TG 2 and TG 3 had systolic blood pressures of 147.2 mm/Hg, 168.2 mm/Hg, and 126.3 mm/Hg, respectively. This systolic blood pressure was lower than the disease control vehicle-treated rodents, which had a systolic blood pressure of 167.2 mm/Hg. The diastolic blood pressure was 119.7 mm/Hg, 124.7 mm/Hg and 88.83 mm/Hg, respectively and that of the disease control vehicle-treated rodents was 122.3 mm/Hg. TG 3 had comparable decrease in the MABP to Telmisartan. These encouraging results make compound TG 3 effective anti-hypertensive drug candidate and worthy of further investigation.
Keywords
Hypertension; Synthesis; Characterization; Non-peptide AT1 Receptor Antagonist; Renin-Angiotensin System
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