Relationship between Type 2 Diabetes Mellitus and the occurrence of Gastroesophageal varices in patients with chronic Hepatitis C Virus Related Liver Cirrhosis | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 1, Volume 73, Issue 8, October 2018, Page 7196-7203 PDF (378.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2018.17787 | ||||
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| Authors | ||||
| Fathy G. Abdel-Raziq1; Mahmoud S. Berengy1; Ahmed RA Mohammed1; Tarek M. Emran2 | ||||
| 1Internal Medicine Department, Faculty of Medicine, Al-Azhar University (Damietta) | ||||
| 2Clinical Pathology Department, Faculty of Medicine, Al-Azhar University (Damietta) | ||||
| Abstract | ||||
| Background: Hepatitis C virus (HCV) infection is a challenging health problem in Egypt. Esophageal varices are a major complication of it which may bleed and endanger patient's life. Aim of the work: to assess the relationship between type-2 DM and the development of gastroesophageal varices and explore the role of insulin resistance as a predictor of gastroesophageal varices. Patients and methods: This study included 100 patients with Child A, HCV-induced cirrhosis. They were divided into two main groups: Group A included 50 patients with type-2 DM, while Group B: included 50 non-diabetic which were subdivided into: Group B1: patients without DM but, with insulin resistance (IR) {32}, and Group B2: patients without DM or IR {18}. All patients were subjected to full history taking, clinical examination, laboratory and imaging studies (abdominal ultrasound) and upper GI endoscopy. Results: The prevalence of esophageal varices in patients with Child A HCV-induced cirrhosis was 80%, elevated to 88% in patients with type-2 DM. Insulin resistance played the major role in development of esophageal varices. There are statistically significant elevated HOMA-IR score, lower platelet count/spleen diameter ratio and higher right liver lobe diameter/albumin ratio in patients with varices. Conclusion: Insulin resistance is a major contributor for development of esophageal varices in HCV induced cirrhosis. Platelet count/spleen diameter ratio, right liver lobe diameter/albumin ratio and insulin resistance measured by HOMA-IR are good predictors for the presence of esophageal varices. | ||||
| Keywords | ||||
| Type-2 diabetes mellitus; Insulin Resistance; hepatitis C virus infection; gastroesophageal varices | ||||
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