SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES
Abd El-Samii, Z., El-Feky, S., Abedel-Fattah, H., Soliman, M. (2004). SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES. EKB Journal Management System, 13(2), 6-15. doi: 10.21608/zjps.2004.177894
Zakaria Abd El-Samii; Said El-Feky; Hanan Abedel-Fattah; Mahmoud Soliman. "SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES". EKB Journal Management System, 13, 2, 2004, 6-15. doi: 10.21608/zjps.2004.177894
Abd El-Samii, Z., El-Feky, S., Abedel-Fattah, H., Soliman, M. (2004). 'SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES', EKB Journal Management System, 13(2), pp. 6-15. doi: 10.21608/zjps.2004.177894
Abd El-Samii, Z., El-Feky, S., Abedel-Fattah, H., Soliman, M. SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES. EKB Journal Management System, 2004; 13(2): 6-15. doi: 10.21608/zjps.2004.177894

SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences
Article 2, Volume 13, Issue 2, December 2004, Page 6-15  XML PDF (3.75 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2004.177894
View on SCiNiTO View on SCiNiTO
Authors
Zakaria Abd El-Samii email 1; Said El-Feky1; Hanan Abedel-Fattah2; Mahmoud Soliman2
1Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
Abstract
4-Chloro-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine (3) was reacted with 4-aminoacetophenone in ethanol to give 4(4- acetylanilino)5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine (4). Compound 4 was used as a key intermediate for the synthesis of several pyrazoles 6-8, pyridones 13, 14, thiazoles 15, 17 and thiazolidinones 18, 19. On the other hand, compound 3 was fused with ethyl 2-amino-4,5,6,7-tetrahydrobenzofbthiophene-3-carboxylate and anthranilic acid to give compound 9 and 10 respectively. Compound 14b showed the same antiinflammatory activity as that of the reference drug dichlofenac sodium.
Statistics
Article View: 60
PDF Download: 49