SPECTROPHOTOMETRIC DETERMINATION OF DAPSONE AND TRANEXAMIC ACID USING HANTZSCH REACTION AND ITS APPLICATION IN PHARMACEUTICAL FORMULATIONS | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 2, Volume 13, Issue 1, June 2004, Page 6-11 PDF (2.3 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.2004.177900 | ||||
View on SCiNiTO | ||||
Authors | ||||
Marwa Elazazy 1; Abdalla Shalaby2; Mohamed Elbalkiny2; Hawa Khalil2 | ||||
1Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt | ||||
2Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||||
Abstract | ||||
A simple, rapid, sensitive and specific spectrophotometric method has been developed for the determination of two primary amines of pharmaceutical interest; dapsone and tranexamic acid. The method is based on condensation of the cited drugs with acetylacetone - formaldehyde mixture in acetic acid - sodium acetate buffer media by aid of heating at (97± 0.5°C) for a fixed time to yield a yellow colored condensation product ''dihydrolutidine derivative'' and possess a characteristic absorption maxima at 330 -345 nm. The variables affecting color development and the stability of the reaction product have been investigated and the conditions optimized. Beer's law is obeyed in the concentration range of 1 - 11 µg ml-1 with molar absorpitivities ranging from 1.475x104-2.015x104 L.mol-1cm-1 and Sandell sensitivities of 8.11x10-3-9.38x10-3 µg cm-2. The proposed spectrophotometric procedure was applied successfully for the determination of the cited drugs in some of their pharmaceutical formulations. | ||||
Statistics Article View: 75 PDF Download: 39 |
||||