SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF LISINOPRIL IN PHARMACEUTICAL FORMULATION
Abdellatef, H., El-Henawee, M., El-Sayed, H., Ayad, M. (2003). SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF LISINOPRIL IN PHARMACEUTICAL FORMULATION. EKB Journal Management System, 12(2), 6-10.
Hisham Abdellatef; Magda El-Henawee; Heba El-Sayed; Magda Ayad. "SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF LISINOPRIL IN PHARMACEUTICAL FORMULATION". EKB Journal Management System, 12, 2, 2003, 6-10.
Abdellatef, H., El-Henawee, M., El-Sayed, H., Ayad, M. (2003). 'SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF LISINOPRIL IN PHARMACEUTICAL FORMULATION', EKB Journal Management System, 12(2), pp. 6-10.
Abdellatef, H., El-Henawee, M., El-Sayed, H., Ayad, M. SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF LISINOPRIL IN PHARMACEUTICAL FORMULATION. EKB Journal Management System, 2003; 12(2): 6-10.

SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF LISINOPRIL IN PHARMACEUTICAL FORMULATION

Zagazig Journal of Pharmaceutical Sciences
Article 2, Volume 12, Issue 2, December 2003, Page 6-10  XML PDF (2.25 MB)
Document Type: Original Article
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Authors
Hisham Abdellatef email 1; Magda El-Henawee2; Heba El-Sayed3; Magda Ayad4
1Analytical Chemistry Department , Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
2Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt
3Analytical Chemistry, Faculty of Pharmacy, Department of Zagazig University - Zagazig - Egypt
4Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.
Abstract
Three simple and sensitive spectrophotometric methods for the determination of lisinopril in tablets are developed. The first method involves oxidation of lisinopril with 1-chlorobenzotriazole reagent (CBT) in strong alkaline medium followed by measuring the absorbance at 350 nm. The method obeys Beer\''s law over concentration range 8-64 µg ml-1 with mean recovery 99.28±1.088. The second method involves the reaction of the primary amino group of lisinopril with ninhydrin reagent producing a coloured product with absorbance maximum at 564 nm. The linearity range was found to be 4 - 20 µgml-1 with mean recovery 99.09±1.069.The third method is based on the coupling reaction with 1,2-naphthaquinone-4-sulphonate (NQS) to form a coloured product (ʎmax: 305). Regression analysis of a Beer''s plot showed good correlation in concentration 4-24 µg ml-1 with mean recovery 99.40± 0.891. The optimum experimental parameters for the reactions have been studied and the reactions mechanisms are discussed. The validity of the described procedures was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The suggested procedures could be used for the determination of lisinopril in tablets. The procedures were rapid, simple and sensitive for quality control application.
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