Serum Leptin in Patients with Chronic Renal Failure on Different Modes of Management
EL-Mougi, H., Abo EL-Yazeed, S., Yousry, Z., Abdel Fattah, A. (2006). Serum Leptin in Patients with Chronic Renal Failure on Different Modes of Management. EKB Journal Management System, 25(1), 610-619. doi: 10.21608/ejhm.2006.17803
Hala M. EL-Mougi; Samiha Abo EL-Yazeed; Zeinab A. Yousry; Abir Abdel Fattah. "Serum Leptin in Patients with Chronic Renal Failure on Different Modes of Management". EKB Journal Management System, 25, 1, 2006, 610-619. doi: 10.21608/ejhm.2006.17803
EL-Mougi, H., Abo EL-Yazeed, S., Yousry, Z., Abdel Fattah, A. (2006). 'Serum Leptin in Patients with Chronic Renal Failure on Different Modes of Management', EKB Journal Management System, 25(1), pp. 610-619. doi: 10.21608/ejhm.2006.17803
EL-Mougi, H., Abo EL-Yazeed, S., Yousry, Z., Abdel Fattah, A. Serum Leptin in Patients with Chronic Renal Failure on Different Modes of Management. EKB Journal Management System, 2006; 25(1): 610-619. doi: 10.21608/ejhm.2006.17803

Serum Leptin in Patients with Chronic Renal Failure on Different Modes of Management

The Egyptian Journal of Hospital Medicine
Article 5, Volume 25, Issue 1, October 2006, Page 610-619  XML PDF (688.71 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2006.17803
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Authors
Hala M. EL-Mougi1; Samiha Abo EL-Yazeed2; Zeinab A. Yousry2; Abir Abdel Fattah2
1Departments of Medical Biochemistry Faculty of Medicine (Girls), AL-Azhar University
2Internal Medicine Faculty of Medicine (Girls), AL-Azhar University
Abstract
Aim:Tostudyserumleptinlevelinchronicrenalfailure(CRF)patientsondifferent modesofmanagementandtoanalyzetheimpactofthemodeoftherapyonserumleptinlevel.
SubjectsandMethods:Thisstudywasconductedon64patients(33males&31females) withchronicrenalfailuredividedintothreegroups:groupI:Twenty-sixpatientstreated conservativelyanddidnotstartdialysisyet(predialysis),groupII:Twenty-fourpatientstreated byhemodialysis,groupIII:Fourteenpatientstreatedbycontinuousambulatoryperitoneal dialysis(CAPD).Twentyhealthysubjectswereincludedascontrolgroup.Allpatientsand controlsweresubjectedtofullclinicalexaminationincludingheightandweighttocalculate bodymassindex(BMI).Bloodureaandserumcreatinineweremeasuredasrenalfunctiontests. SerumleptinwasmeasuredbyEASIAandsoseruminsulin.
Results:InpredialysisandCAPDgroups,thereisasignificantincreaseinleptin,leptin/ BMIandinsulininpatientsincomparisontocontrolsubjects.Inhemodialysisgroup,thereisa significantincreaseinleptinandleptin/BMIandanon-significantincreaseininsulinlevelin patientsincomparisontocontrolsubjects.Insulinissignificantlycorrelatedwithleptininthe firstgroup,whileinthesecondandthirdgroupsthereisnocorrelation.Thehighestleptinlevel isfoundintheCAPDgroupofpatientsfollowedbythepredialysisonethenthehemodialysis group.
Leptinlevelissignificantlyhigherinfemalesthanmalesinallgroups.Thisdifference remainedafteradjustingleptinleveltoBMI.
Nocorrelationwasfoundbetweenleptinlevelandageorbetweenleptinlevelandrenal functioninthethreegroupsofpatients.Nocorrelationwasfoundbetweenleptinlevelandthe durationofdialysisinthehemodialysisandCAPDgroups.
Conclusion:SerumleptiniselevatedinCRFpatientsirrespectiveofthetypeof managementtheyareundergoing.Dialysis,hasnosignificanteffectonleptinlevel.Thetwo mainpredictorsofserumleptinlevelaresexandBMIinCRFpatientsandinhealthysubjects.



Leptinlevelmayserveasavaluableclinical Introduction
Leptinisa16KDproteinhormone producedmainlybywhiteadiposetissue (Kuwaharaetal.,2003).Itisinvolvedin energyhomeostasisthatactstoinhibitfood intake,tostimulateenergyexpenditureand influenceinsulinsecretion,lipolysisand sugartransport(Mistriketal.,2004).
Theactionofleptinismediated throughtheleptinreceptor(Ob-R),whichis encodedbythediabetes(db)gene.Leptin receptorsisoformshavebeenreportedin widevarietyoftissues:heart,lung,


markerforbodyadiposity.
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