Evaluation of the effect of the cumulative centrifugation force on the characteristics and the tissue regeneration potential of the platelet rich fibrin: a clinical and laboratory study | ||||
| Egyptian Journal of Oral and Maxillofacial Surgery | ||||
| Article 3, Volume 11, Issue 3, July 2020, Page 96-102 PDF (342.36 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/omx.2021.48981.1095 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Mosaad Khalifah  
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| Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kafr ElSheikh University, Kafr ElSheikh, Egypt | ||||
| Abstract | ||||
| Background: Although the platelet-rich fibrin (PRF) gained a considerable popularity as a tissue regeneration technique to reconstruct the surgical defets, the effect of the cumulative centrifugation force (in terms of speed and time) on its regeneration potential is unclear. Material and Methods: Ten patients with maxillary surgical defects were randomly and equally divided into two groups where in the study group, the centrifugation speed and time were 1500 rpm and 18 minutes respectively and in the control group, these centrifugation parameters were 2700 rpm and 12 minutes on order. For each patient, the surgical defect was packed with the clots and an extra clot was assigned for histologic, immunohistochemical and histomorphometric examination. Results: The laboratory results exhibited that the slower but longer duration centrifugation resulted in a looser fibrin clot with larger interfiber spaces and deeper penetration of neutrophilic granulocytes. In both groups, the other cells (except for platelets which were distributed through out the clot) were confined to the proximal ⅓ - ¼ of the clot. But that difference failed to impact the regeneration potential on the clinical level as assessed by bone formation scale and density changes. Conclusion: Although changing the comulative centrifugation force resulted in deeper penetration of granulocytes, the regenerative potential did not enhance, perhaps due to the complex nature of the regeneration process where one element alone cannot alter the regeneration potential. | ||||
| Keywords | ||||
| Bone; Cell distribution; Cumulative centrifugation force; PRF and Regeneration | ||||
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