Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation
Khorshed, S., Fayed, A., Kamel, L., Awad, S. (2015). Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation. EKB Journal Management System, 5(2), 102-114. doi: 10.21608/aeji.2015.17819
Soha E Khorshed; Alaa Fayed; Lamiaa Mahmoud Kamel; Shereen M Awad. "Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation". EKB Journal Management System, 5, 2, 2015, 102-114. doi: 10.21608/aeji.2015.17819
Khorshed, S., Fayed, A., Kamel, L., Awad, S. (2015). 'Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation', EKB Journal Management System, 5(2), pp. 102-114. doi: 10.21608/aeji.2015.17819
Khorshed, S., Fayed, A., Kamel, L., Awad, S. Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation. EKB Journal Management System, 2015; 5(2): 102-114. doi: 10.21608/aeji.2015.17819

Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation

Afro-Egyptian Journal of Infectious and Endemic Diseases
Article 7, Volume 5, Issue 2, June 2015, Page 102-114  XML PDF (516.48 K)
Document Type: Original Article
DOI: 10.21608/aeji.2015.17819
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Authors
Soha E Khorshed1; Alaa Fayed2; Lamiaa Mahmoud Kamel3; Shereen M Awad4
1Tropical Medicine Department , Faculty of Medicine, Zagazig University, Egypt
2Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine Zagazig University, Egypt
3Clinical pathology Department, Faculty of Medicine Zagazig University, Egypt
4Family Medicine Department , Faculty of Medicine Zagazig University, Egypt
Abstract
Background and study aim : Many studies have reported that insulin resistance raises the risk of primary hepatocellular carcinoma (HCC). Caspase-generated cytokeratin-18 (CK-18) fragments are produced during apoptosis of hepatic cells. The present study aims to evaluate the value of serum CK-18 and the impact of insulin resistance on recurrence of HCV related HCC in patients treated with radiofrequency ablation (RFA). .
Patients and Methods: The present study was conducted on 60 HCV patients. Group I: 30 patients with HCC treated by RFA and group II: 30 non HCC cirrhotic patients. Insulin resistance was estimated by the homeostatic model assessment of insulin resistance (HOMA-IR) and CK-18 level was measured for all patients using ELISA.
Results: HOMA-IR and CK-18 levels were significantly elevated in HCC patients when compared to non HCC cirrhotic patients. There was a significant increase in CK-18 and HOMA-IR levels in patients with local recurrence versus those with no recurrence (p<0.001). Univariate analysis revealed that HOMA-IR (p=<0.001) and CK-18 (p=<0.001) were significant predictors of recurrence of HCC.
Conclusion: CK-18 and HOMA-IR are potential prognostic markers as they can predict the recurrence of HCC.
Keywords
Hepatocellular carcinoma; homeostatic model assessment of insulin resistance; Caspasegenerated cytokeratine-18; Radiofrequency ablation
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