Delayed surgery of locally advanced low rectal cancer after preoperative concurrent chemo-radiotherapy, trial for sphincter- saving radical resection with good local control
Mahmoud, O., Maged, H., Fawzy, G., Hussein, A., Ghali, R., El-Ghoneimy, K. (2010). Delayed surgery of locally advanced low rectal cancer after preoperative concurrent chemo-radiotherapy, trial for sphincter- saving radical resection with good local control. EKB Journal Management System, 3(2), 111-117. doi: 10.21608/asjs.2010.178460
Osama Mahmoud; Hesham Maged; Gamal Fawzy; Ahmed Hussein; Ramy Ghali; Khaled El-Ghoneimy. "Delayed surgery of locally advanced low rectal cancer after preoperative concurrent chemo-radiotherapy, trial for sphincter- saving radical resection with good local control". EKB Journal Management System, 3, 2, 2010, 111-117. doi: 10.21608/asjs.2010.178460
Mahmoud, O., Maged, H., Fawzy, G., Hussein, A., Ghali, R., El-Ghoneimy, K. (2010). 'Delayed surgery of locally advanced low rectal cancer after preoperative concurrent chemo-radiotherapy, trial for sphincter- saving radical resection with good local control', EKB Journal Management System, 3(2), pp. 111-117. doi: 10.21608/asjs.2010.178460
Mahmoud, O., Maged, H., Fawzy, G., Hussein, A., Ghali, R., El-Ghoneimy, K. Delayed surgery of locally advanced low rectal cancer after preoperative concurrent chemo-radiotherapy, trial for sphincter- saving radical resection with good local control. EKB Journal Management System, 2010; 3(2): 111-117. doi: 10.21608/asjs.2010.178460

Delayed surgery of locally advanced low rectal cancer after preoperative concurrent chemo-radiotherapy, trial for sphincter- saving radical resection with good local control

Ain Shams Journal of Surgery
Article 2, Volume 3, Issue 2, July 2010, Page 111-117  XML PDF (37.22 K)
Document Type: Original Article
DOI: 10.21608/asjs.2010.178460
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Authors
Osama Mahmoud1; Hesham Maged1; Gamal Fawzy1; Ahmed Hussein1; Ramy Ghali2; Khaled El-Ghoneimy2
1Department of General Surgery, Ain Shams University, Cairo, Egypt
2Department of Clinical Oncology, Ain Shams University, Cairo, Egypt.
Abstract
To evaluate multimodality treatment therapy in patients with locally advanced low rectal adenocarcinoma as a trial for sphincter-saving radical resection with good local control. Twenty two patients underwent preoperative concurrent chemoradiotherapy, (CCRT) and radical resection for locally advanced low rectal adenocarcinoma. Patients received preoperative bolus
5-fluorouracil (5-FU) and leucovorin concurrent with radiotherapy to a total dose of 50.4 Gy, followed by radical resection surgery 6 weeks after CCRT. Fifty-five percent of patients achieved tumor downstaging, 14% of patients showed pathological complete remission, sphincter-saving rate was 82%, and there were no deaths related to preoperative CCRT or surgery. Mild hematological and gastrointestinal toxicity was noted during the course of preoperative CCRT. Overall, 3-year survival rate was 78% and the rate of locoregional recurrence was 13.6%. This study showed that many patients with locally advanced rectal cancer can be operated on with sphincter-saving radical resection surgery under good local control after preoperative CCRT which induces tumor downstaging.
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