Synthesis, Reactions and Antitumor Activity of Certain 1,3-diphenylpyrazole-4-carboxaldehyde Derivatives
Amer, A., Ramses, N., Mahgoub, S. (2018). Synthesis, Reactions and Antitumor Activity of Certain 1,3-diphenylpyrazole-4-carboxaldehyde Derivatives. EKB Journal Management System, 61(Conference issue (14th Ibn Sina Arab Conference on Heterocyclic Chemistry and its Applications (ISACHC 2018), 30 March-2 April 2018, Hurgada, Egypt).), 51-65. doi: 10.21608/ejchem.2018.5328.1470
Atef Amer; Neveen Ramses; Sebaey Mahgoub. "Synthesis, Reactions and Antitumor Activity of Certain 1,3-diphenylpyrazole-4-carboxaldehyde Derivatives". EKB Journal Management System, 61, Conference issue (14th Ibn Sina Arab Conference on Heterocyclic Chemistry and its Applications (ISACHC 2018), 30 March-2 April 2018, Hurgada, Egypt)., 2018, 51-65. doi: 10.21608/ejchem.2018.5328.1470
Amer, A., Ramses, N., Mahgoub, S. (2018). 'Synthesis, Reactions and Antitumor Activity of Certain 1,3-diphenylpyrazole-4-carboxaldehyde Derivatives', EKB Journal Management System, 61(Conference issue (14th Ibn Sina Arab Conference on Heterocyclic Chemistry and its Applications (ISACHC 2018), 30 March-2 April 2018, Hurgada, Egypt).), pp. 51-65. doi: 10.21608/ejchem.2018.5328.1470
Amer, A., Ramses, N., Mahgoub, S. Synthesis, Reactions and Antitumor Activity of Certain 1,3-diphenylpyrazole-4-carboxaldehyde Derivatives. EKB Journal Management System, 2018; 61(Conference issue (14th Ibn Sina Arab Conference on Heterocyclic Chemistry and its Applications (ISACHC 2018), 30 March-2 April 2018, Hurgada, Egypt).): 51-65. doi: 10.21608/ejchem.2018.5328.1470

Synthesis, Reactions and Antitumor Activity of Certain 1,3-diphenylpyrazole-4-carboxaldehyde Derivatives

Egyptian Journal of Chemistry
Article 34, Volume 61, Conference issue (14th Ibn Sina Arab Conference on Heterocyclic Chemistry and its Applications (ISACHC 2018), 30 March-2 April 2018, Hurgada, Egypt)., November and December 2018, Page 51-65  XML PDF (851.9 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2018.5328.1470
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Authors
Atef Amer email 1; Neveen Ramses1; Sebaey Mahgoub2
1Department of Chemistry, Faculty of Science, Zagazig University, Egypt,
2Research and Development, Unipharma, El-Obour City, Egypt
Abstract
In continuation of our interest in synthesis of novel heterocycles with anticipated biological activity especially the antitumor activity. In this paper we have discussed synthesis and reaction of 1,3-diphenylpyrazol-4-carboxaldehyde 4 with acetophenone derivatives 1a–d, active methylene compounds, hydrazines and aniline derivatives to yield the expected derivatives 5a–d. Also, a series of penta-substituted pyridine derivatives 15a-e have been synthesized by one-pot three component cyclocondensation reaction of 1,3-diphenylpyrazole-4-carboxaldehyde 1, malononitrile and thiol derivatives 13a–e in presence of triethylamine as a catalyst. Also, 2-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(aryl)thiazolidine-4-one 20a-e has been synthesized from N-((1,3-diphenyl-1H-pyrazol-4-yl)methylene-aniline derivatives 11a-e and thioglycolic acid. Some of the synthesized derivatives were screened for their antitumor activity. All the newly synthesized compounds have been characterized by means of elemental analyses, IR, 1H NMR, 13C NMR, MS and in some cases by comparison with the known properties of compound or by comparison with samples prepared by reported unambiguous routs.
Keywords
1; 3-diphenylpyrazol-4-carboxaldehyde; Vilsmeier-Haack reaction; 3; 5-Pyridine dicarbonitrile; antitumor activity
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