Chemical and Biological Diversity in Nephthea Soft Corals in the Current Decade: A Review

Allam, Khaled M.; Khedr, Amgad I.M.; Allam, Ahmed E.; Abdelkader, Mohamed Salaheldin A.; Elkhayat, Ehab S.; Fouad, Mostafa A.

doi:10.21608/jabps.2021.62966.1121

	Chemical and Biological Diversity in Nephthea Soft Corals in the Current Decade: A Review
Journal of advanced Biomedical and Pharmaceutical Sciences
Article 2, Volume 4, Issue 3, July 2021, Page 124-133 PDF (935.41 K)
Document Type: Review Articles
DOI: 10.21608/jabps.2021.62966.1121
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Authors
Khaled M. Allam ¹; Amgad I.M. Khedr²; Ahmed E. Allam³; Mohamed Salaheldin A. Abdelkader ⁴; Ehab S. Elkhayat⁵; Mostafa A. Fouad ⁶
¹Department of Pharmacognosy, Faculty of Pharmacy, South Valley University
²Department of Pharmacognosy, Faculty of Pharmacy, Port Said University, Port Said P.O. Box 42526 Egypt. Faculty of Pharmacy, Horus University-Egypt, New Damietta, P.O. Box 34518 Egypt.
³Pharmacognosy Dept., Faculty of Pharmacy, Al-Azhar University, Assiut Branch.
⁴Department of Pharmacognosy, Faculty of Pharmacy, Sohag University, Nasr City, Eastern Avenue, P.O. Box 11432, Sohag, Egypt.
⁵Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut P.O. Box 71524, Egypt.
⁶Department of Pharmacognosy, Faculty of Pharmacy, Minia University, P.O. Box 61519 Minia, Egypt.
Abstract
Marine natural products play an important role within the innovation of lead compounds for drug development. The soft coral genus Nephthea has proven to be a treasurable source to discover new natural products with biological potentials. This review provides a survey of all metabolites isolated from the genus Nephthea in the current decade, along with their natural sources, chemical structures and biological potentials whenever possible. The current review aimed to compare chemical and biological diversity in the soft corals genus Nephthea. We listed 54 compounds including steroids and diterpenes. The steroids are the most abundant compounds of the genus Nephthea (74 %) followed by diterpenes (20%) and miscellaneous compounds (6%). The isolated compounds from genus Nephthea in the current decade have been shown different biological activities as cytotoxic against different cancer cell lines (29 compounds), as anti-inflammatory (13 compounds), antifouling (3 compounds) and antibacterial (2 compounds).
Keywords
Soft corals; Nephthea; Diterpenes; Steroids; Cytotoxicity


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