Docking and Synthesis of Some 2-Aminothiazole Derivatives as Antimicrobial Agents | ||||
| Egyptian Journal of Chemistry | ||||
| Article 42, Volume 64, Issue 12, December 2021, Page 7269-7276 PDF (597.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.79221.3891 | ||||
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| Authors | ||||
| Linda R. Abdu-Rahem1; Ahmad Kh. Ahmad1; Faris T. Abachi* 2 | ||||
| 1Department of Chemistry, College of Education for Pure Science, | ||||
| 2Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq. | ||||
| Abstract | ||||
| The 2- aminothiazole compounds are medicinally important agents due to their broad spectrum of biological activities. This study aims to design new 2-aminothiazole derivatives, docking, and synthesis via several steps and identified using physical and spectroscopic techniques. The bioactivities of the synthesized compounds were evaluated concerning their antimicrobial activities against were screened against five bacterial strains, Enterobact aerogenes, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus and two types of fungal strain Candida albicans and Cryptococcus neoformans var. grubii. | ||||
| Keywords | ||||
| : 2-aminothiazole; E.coli; antimicrobial activities; C.albicans | ||||
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