The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies) | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 10, Volume 24, Issue 1, July 2006, Page 524-538 PDF (2.15 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhm.2006.17916 | ||||
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Authors | ||||
Hanaa F. Waer; Saleh Edress | ||||
National Center for Radiation Research and Technology, Atomic Energy Authority Faculty of Medicine,Banha University | ||||
Abstract | ||||
Foodadditivesarechemicalsubstancesaddedintentionallytofoodstuffstopreserve, color,sweetenandflavorfood.Monosodiumglutamate(MSG)isusedasaflavorenhancerand foundinmostsoups,saladdressingandprocessedmeat.TheuseofMSGinfoodisgrowing. Irrationalfearhadincreasedinthelastfewyearsduetotheadversereactionsandtoxicityof MSG. ThepresentstudywasdesignedtoinvestigatetheeffectofMSGontheratliverandthe amelioratingeffectoftaurineanalog“Guanidinoethanesulfonicacid(GES)”.Sixtyalbinorats (2-3monthsold)wereusedinthepresentstudy.MSGwasgivenorallyatadailydoseof60 mg/1000gforonemonth,twomonthsandwasgivenatadailydoseof100mg/1000gmforone month.TheresultsrevealedthatthedeleteriouseffectsofMSGweredoserelatedand cumulative.InMSGtreatedrats,theexaminedsectionsshowedremarkablealterationsvaried considerablyfrommoderatestructuralchangestocytoplasmiclysisandsignsofdegenerationof cellularorganelles.Thehistologicalchangesshoweddisturbedliverarchitecture,hemorrhagein thecentralveins,areasofnecrosis,vacuolationandincreasedinflammatorycellsinfiltration. Theglycogengranulesincreasedaswellasthecollagenfibersinthelivercells.Ultrastructural changesshowedlossofcytoplasmicdifferentiation,vacuolation,pyknoticnucleiwithirregular nuclearmembranesandelongatedelectrondensemitochondria.Conversely,treatmentofrats withtaurineanalog(GES)significantlyattenuatedthecellulartoxicityofMSG. | ||||
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