A Histological Study on the Possible Adverse Effect of Sofosbuvir on Lungs of Adult Male Albino Rats | ||||
| Journal of Medical Histology | ||||
| Article 9, Volume 4, Issue 1, June 2020, Page 119-125 PDF (1.62 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jmh.2020.33529.1077 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sara Hosny  ; Manal Abdel Mohsen ; Marwa Mohamed Sabry Sabry
| ||||
| Departments of of Histology, Faculty of Medicine, Cairo university, Egypt. | ||||
| Abstract | ||||
| Background: In 2011, three new direct-acting antivirals (DAAs) for HCV including sofosbuvir were accredited for HCV management. Aim: To evaluate the impact of Sofosbuvir treatment on the histological structure of the lungs of adult male albino rat. Materials and Methods: 15 male rats were classified into: control group of 5 rats and sofosbuvir treated group of 10 rats that received sofosbuvir orally in a dose of 4 mg/kg per day for 5 weeks. Blood samples were drawn to assess serum Transforming growth factor- β (TGF-β). Lung specimens were obtained for evaluation by light microscope. Alpha smooth Muscle Actin (α-SMA), E-cadherin immunohistochemistry, and statistical analysis were applied. Results: Marked increase in the mean value of serum TGF-β in Sofosbuvir treated group when compared to control group. Sofosbuvir resulted in histological and immunohistochemical changes in the lungs of sofosbuvir treated rats. Conclusion: Severe lung injury was detected after treatment with sofosbuvir. However further studies should be done to determine the exact mechanism and more caution should be taken during administration of sofosbuvir. | ||||
| Keywords | ||||
| Alpha smooth muscle actin; E-cadherin; Lung; sofosbuvir; TGF-β | ||||
|
Statistics Article View: 181 PDF Download: 455 |
||||
