Effect of Radiotherapy and Chemotherapy on Normal Jejunal Mucosa of Swiss Mice: Histological, Cytological, and Histochemical Studies | ||||
| Journal of High Institute of Public Health | ||||
| Article 2, Volume 35, Issue 1, January 2005, Page 19-34 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jhiph.2005.179269 | ||||
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| Authors | ||||
| Safia M. Hassan1; Yousri S. Goda2 | ||||
| 1Department of Histochemistry and Cell Biology, Medical Research Institute, Egypt | ||||
| 2Radiology Department, Faculty of Medicine, Alexandria University, Egypt | ||||
| Abstract | ||||
| Radiation and Chemotherapy play a major role in the management of patients with malignant tumours, they have marked toxicity against tumour cells in addition to other undesirable side effects on normal organs. This led the researchers to carry out histological, cytological, and histochemical studies as regards the effect of radiation and chemotherapy on the jejunal mucosa of normal mice. Seventy-two male Swiss mice were used in this study. Golgi apparatus, acid phosphatase [ACP], and succinic dehydrogenase [SDH] enzymes were studied in normal jejunum as well as after exposure to radiotherapy and chemotherapy. The results revealed that prominent changes were observed in cisplatin-treated group, while more effects were shown in animals receiving combined radio and chemotherapy. | ||||
| Keywords | ||||
| Radiotherapy; Chemotherapy; Normal Jejunal Mucosa; Swiss Mice | ||||
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