PATHOLOGICAL STUDIES ON BCG AND HYPERICIN MEDIATED PHOTODYNAMIC THERAPY (PDT) IN TUMOR TREATMENT IN MICE
AL KLAMAWE, N., EL-BEGAWY, M., SHEHAB, G., SHALABY, A. (2011). PATHOLOGICAL STUDIES ON BCG AND HYPERICIN MEDIATED PHOTODYNAMIC THERAPY (PDT) IN TUMOR TREATMENT IN MICE. EKB Journal Management System, 89(4), 1563-1576. doi: 10.21608/ejar.2011.179534
NAGLAA M. AL KLAMAWE; MAHMOUD B. EL-BEGAWY; GEHAN G. SHEHAB; ADEL A. SHALABY. "PATHOLOGICAL STUDIES ON BCG AND HYPERICIN MEDIATED PHOTODYNAMIC THERAPY (PDT) IN TUMOR TREATMENT IN MICE". EKB Journal Management System, 89, 4, 2011, 1563-1576. doi: 10.21608/ejar.2011.179534
AL KLAMAWE, N., EL-BEGAWY, M., SHEHAB, G., SHALABY, A. (2011). 'PATHOLOGICAL STUDIES ON BCG AND HYPERICIN MEDIATED PHOTODYNAMIC THERAPY (PDT) IN TUMOR TREATMENT IN MICE', EKB Journal Management System, 89(4), pp. 1563-1576. doi: 10.21608/ejar.2011.179534
AL KLAMAWE, N., EL-BEGAWY, M., SHEHAB, G., SHALABY, A. PATHOLOGICAL STUDIES ON BCG AND HYPERICIN MEDIATED PHOTODYNAMIC THERAPY (PDT) IN TUMOR TREATMENT IN MICE. EKB Journal Management System, 2011; 89(4): 1563-1576. doi: 10.21608/ejar.2011.179534

PATHOLOGICAL STUDIES ON BCG AND HYPERICIN MEDIATED PHOTODYNAMIC THERAPY (PDT) IN TUMOR TREATMENT IN MICE

Egyptian Journal of Agricultural Research
Article 22, Volume 89, Issue 4, December 2011, Page 1563-1576  XML PDF (994.51 K)
Document Type: Original Article
DOI: 10.21608/ejar.2011.179534
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Authors
NAGLAA M. AL KLAMAWE1; MAHMOUD B. EL-BEGAWY2; GEHAN G. SHEHAB1; ADEL A. SHALABY2
1Animal Health Research Institute, Agricultural Research Center, Ministry of Agriculture, Dokki, Giza, Egypt.
2Faculty of Veterinary Medicine, Beni – Suef University, Beni – Suef, Egypt.
Abstract
The purpose of the current study is to evaluate the effectiveness of Hypericin Photodynamic therapy (PDT) alone or associated with BCG immunization as an oncotherapy in Swiss mice. For this purpose, 90 mature male swiss mice were chosen and equally divided into 5 comparable groups. The first, was a negative control group, the second was hypericin contol group and the third was tumor control group. The forth and fifth groups were the treated groups with Hypericin-PDT and BCG/ Hypericin – PDT, respectively. They were subjected to the treating regimen as follows: a dose of 5 mg/kg body weight of an aqueous ethanolic Hypericin solution was injected by both intra-peritoneal (i.p.) and intratumoral (i.t.) injections, followed 2 hours later by exposure to non-coherent light (590 nm) for 5 minutes in each session. Mice received 5 sessions / week for 6 weeks. Both treatments resulted in pronounced degeneration and necrosis of the neoplastic cells with replacement of tumor masses by fibrous connective tissue. The curative rate was enhanced when Hypericin-PDT was accompanied by BCG as an immuno-stimulating agent. From the pathological pictures, it can be concluded that Hypericin-PDT is an effective treatment for superficial neoplasms. BCG administration, as a non-specific immuno-stimulant, enhances the therapeutic effect of Hypericin -PDT.
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