Leptin Level and Plasma Prothrombotic Factors in Obese Subjects
Ezzat, H., Abd El-Rahman, )., Mousa, S., Mahmoud, E. (2006). Leptin Level and Plasma Prothrombotic Factors in Obese Subjects. EKB Journal Management System, 22(1), 39-48. doi: 10.21608/ejhm.2006.18024
Hamdia Ezzat; )Eman M Abd El-Rahman; Sabilah G Mousa; Eman A Mahmoud. "Leptin Level and Plasma Prothrombotic Factors in Obese Subjects". EKB Journal Management System, 22, 1, 2006, 39-48. doi: 10.21608/ejhm.2006.18024
Ezzat, H., Abd El-Rahman, )., Mousa, S., Mahmoud, E. (2006). 'Leptin Level and Plasma Prothrombotic Factors in Obese Subjects', EKB Journal Management System, 22(1), pp. 39-48. doi: 10.21608/ejhm.2006.18024
Ezzat, H., Abd El-Rahman, )., Mousa, S., Mahmoud, E. Leptin Level and Plasma Prothrombotic Factors in Obese Subjects. EKB Journal Management System, 2006; 22(1): 39-48. doi: 10.21608/ejhm.2006.18024

Leptin Level and Plasma Prothrombotic Factors in Obese Subjects

The Egyptian Journal of Hospital Medicine
Article 4, Volume 22, Issue 1, January 2006, Page 39-48  XML PDF (382.19 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2006.18024
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Authors
Hamdia Ezzat1; )Eman M Abd El-Rahman2; Sabilah G Mousa3; Eman A Mahmoud4
1Clinical Pathology Department, Al-Azhar and Assiut University
2Internal Medicine Department, Al-Azhar and Assiut University
3Internal Medicine Departments, Al-Azhar and Assiut University
4Rheumatology & Rehabilitation Departments, Al-Azhar and Assiut University
Abstract
Obesity is associated with increased cardiovascular morbidity and mortality. Abnormalities in coagulation and haemostasis represent a well-known link between obesity and thrombosis (both arterial and venous).
In human, production of a depocyte-derived peptide, leptin has been linked to adiposity; recent studies have shown that plasminogen activator inhibitor-1 (PAI-1),a prothrombotic factor associated with atherosclerosis complication is also produced in adipose tissue.
Several studies reported that obese subjects had elevated levels of vonWillbrand factor (vWF) and fibrinogen .
The aim of this work is to examine the relationship of obesity, fat distribution and serum leptin concentration with plasma levels of Prothrombotic factors (PAI-1 – (vWF) and fibrinogen) and lipid pattern (Triglycerides and Cholesterol) as metabolic parameters.
The body fat distribution was evaluated by measuring the body mass index ( BMI) and waist-to- hip ratio (WHR).
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