Some Biochemical Parameters Of Young Male Albino Rats Treated With Ponceau 4 R And Vitamin E. | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 7, Volume 22, Issue 1, January 2006, Page 73-79 PDF (257.53 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2006.18028 | ||||
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| Authors | ||||
| Eman G. E. Helal1; Mahmoud A. El-Kassas1; Samer A. M. Zaahkouk1; Hesham G. Abdel-Wahed1; Amany F. Mahmoud2 | ||||
| 1Departments of Zoology –Faculty of Science - Al-Azhar University(Girls) | ||||
| 2Faculty of Home Economics- jeddah, K.S.A. | ||||
| Abstract | ||||
| The current study aimed to clarify hazardous effect of ponceau 4R as food colour on rats and the effect of vitamin E as an antioxidant to prevent its toxic effect. Fourty premature growing male albino rats were divided into four groups, the first served as control group, the second supplemented with vitamin E (150 mg/kg),the third treated with ponceau 4R(0.19 mg/kg) and fourth treated with ponceau 4R(0.19 mg/kg) and vitamin E (150 mg/kg). Half of each group was treated for 3 m, the other half was treated for 6 months. Rats treated with ponceau 4R showed highly significant decrease (P<0.01) in serum total lipids, proteins, albumin levels and cholinesterase activity throughout the experimental period, while recorded a significant decrease (P<0.05) in glucose level till the end of the experiment and in globulin level and A/G ratio after 3 months of treatment only. On the other hand, significant increase was detected in total cholesterol level (P < .01) and AST activity (P < .05) after both periods of treatment, while ALT activity showed insignificant change. It seams from the presents study that vitamin E has protective effect against the side effect of ponceau 4R on rats. | ||||
| Keywords | ||||
| Ponceau 4R; Vitamin E; food colour and antioxidant | ||||
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