Reldan and Ammonium Nitrate Induced Histopatjological and Fine Structural Changes in Testis of Mice | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 1, Volume 21, Issue 1, October 2005, Page 1-15 PDF (2.29 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2005.18044 | ||||
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| Authors | ||||
| Mahmoud, A. El-Banhawy1; Nahed, H.A. Riad1; Mona El-Akkad1; Shadia, A. Radwan2; Aziza El-Wessemy2 | ||||
| 1Zoology Depts, Faculty Science , Ain Shams University | ||||
| 2Biology & Geology Depts, Faculty of Education, Ain Shams University | ||||
| Abstract | ||||
| Two agrochemicals, reldan insecticide and ammonium nitrate fertilizer affected the histopathological and ultrastructural of mice testicular tissue. Mice were divided into 13 groups, the first group served as a control group while the other groups treated with reldan or ammonium nitrate. For each of the agrochemicals used, the 1⁄2 LD50 (12 mg/kg b.wt. for reldan and 90 mg/kg b.wt. for ammonium nitrate) was given as a single dose to 3 groups of mice which were sacrificed after 5, 10 and 15 days post-treatment, and as repeated daily doses to other groups of mice for 5 and 10 days. Animals treated for 5 days were sacrificed 24 hrs after the last dose, while those treated for 10 days were sacrificed 24 hrs or 5 days after the last dose. The applied agrochemicals caused histopathological changes in the testes including, disorganization of the basal lamina and germinal epithelium, maturation arrest at various degrees of degenerated spermatocytes and spermatids in the testicular tissue. Ultrastructural examination showed marked alterations and degeneration of organelles in germ cells, Sertoli cells and Leydig cells. | ||||
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