Role of Harmaline in liver cirrhosis protection via arginase-I activity modulation in liver | ||||
| Biochemistry Letters | ||||
| Article 1, Volume 17, Issue 1, 2021, Page 1-8 PDF (565.46 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/blj.2021.180477 | ||||
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| Authors | ||||
| Doha M. Beltagy1; Khloud Gamal Abdelsalam1; Tarek M Mohamed2; Mai M. El-Keey2 | ||||
| 1Biochemistry Division, Chemistry Department, Faculty of Science, Damanhour University, Egypt. | ||||
| 2Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Egypt. | ||||
| Abstract | ||||
| Background: Liver cirrhosis, the 11th death common cause, is a severe disorder that includes inflammation, oxidative damage, also immune response. Harmaline shows the antioxidant and anti-inflammatory mechanisms that aid in partial protection of hepatic cirrhosis. Objective: This work aimed to evaluate the protection effect of harmaline against liver cirrhosis induced by thioacetamide in mice via arginase-1 enzyme activity modulation. Methods: The study was carried out on forty male mice divided into four groups. Control group (GI), thioacetamide group (GII), harmaline group (GIII), and co-treated group (GIV). By the end of the experiment, arginase-1 activity and liver enzymes were measured in serum and liver tissue. Results: The results showed that combined harmaline administration can cause significant suppression of liver inflammation by increasing ariginase-1 activity to nearly normal values. Inhibition of activated myofibroblasts cells and extracellular matrix accumulation was also noticed. Conclusion: Harmaline has protective role against liver cirrhosis induced by thioacetamide in mice. It can be therapeutically used as a safe liver support after further in vivo studies. | ||||
| Keywords | ||||
| Thioacetamide, Cirrhosis; Harmaline; Arginase; liver | ||||
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